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Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue

Kennedy, B.F., McLaughlin, R.A., Kennedy, K.M., Chin, L., Wijesinghe, P., Curatolo, A., Tien, A., Ronald, M., Latham, B., Saunders, C.M. and Sampson, David (2015) Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue Cancer Research, 75 (16). pp. 3236-3245.

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Abstract

An accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high reexcision rates without resorting to the removal of excess healthy tissue. Optical coherence microelastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to microscale variations of the mechanical properties of tissue. As the tumor modifies the mechanical properties of breast tissue, OCME has the potential to identify, on the microscale, involved regions of fresh, unstained tissue. OCME is based on the use of optical coherence tomography (OCT) to measure tissue deformation in response to applied mechanical compression. In this feasibility study on 58 ex vivo samples from patients undergoing mastectomy or wide local excision, we demonstrate the performance of OCME as a means to visualize tissue microarchitecture in benign and malignant human breast tissues. Through a comparison with corresponding histology and OCT images, OCME is shown to enable ready visualization of features such as ducts, lobules, microcysts, blood vessels, and arterioles and to identify invasive tumor through distinctive patterns in OCME images, often with enhanced contrast compared with OCT. These results lay the foundation for future intraoperative studies.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Kennedy, B.F.
McLaughlin, R.A.
Kennedy, K.M.
Chin, L.
Wijesinghe, P.
Curatolo, A.
Tien, A.
Ronald, M.
Latham, B.
Saunders, C.M.
Sampson, Davidd.sampson@surrey.ac.uk
Date : 2015
DOI : 10.1158/0008-5472.CAN-14-3694
Uncontrolled Keywords : arteriole, Article, breast cancer, breast cyst, breast duct, clinical article, controlled study, elastography, ex vivo study, feasibility study, histopathology, human, human tissue, imaging system, intermethod comparison, mastectomy, optical coherence microelastography, optical coherence microelastography imaging system, optical coherence tomography, partial mastectomy, priority journal, tumor blood flow, wide excision, breast, Breast Neoplasms, devices, elastography, female, pathology, procedures, reproducibility, sensitivity and specificity, three dimensional imaging, Breast, Breast Neoplasms, Elasticity Imaging Techniques, Feasibility Studies, Female, Humans, Imaging, Three-Dimensional, Reproducibility of Results, Sensitivity and Specificity, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 08:26
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846776

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