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Wide-field optical coherence microelastography for intraoperative assessment of human breast cancer margins

Allen, W.M., Chin, L., Wijesinghe, P., Kirk, R.W., Latham, B., Sampson, David, Saunders, C.M. and Kennedy, B.F. (2016) Wide-field optical coherence microelastography for intraoperative assessment of human breast cancer margins Biomedical Optics Express, 7 (10). pp. 4139-4153.

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Abstract

Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Allen, W.M.
Chin, L.
Wijesinghe, P.
Kirk, R.W.
Latham, B.
Sampson, Davidd.sampson@surrey.ac.uk
Saunders, C.M.
Kennedy, B.F.
Date : 2016
DOI : 10.1364/BOE.7.004139
Uncontrolled Keywords : Medical optics and biotechnology, Optical coherence tomography, Medical imaging, Optical tomography, Tissue, Transplantation (surgical), Breast conserving surgery, Human breast cancer, Human breast tissue, Internal diameters, Lumpectomy specimen, Malignant tissues, Medical optics and biotechnology, Surgical procedures, Surgery, Article, breast cancer, disease assessment, elastography, histopathology, human, human tissue, image processing, imaging phantom, optical coherence microelastography, partial mastectomy, peroperative care, signal noise ratio, tissue preparation, tumor volume
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 04 Jun 2018 09:00
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846757

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