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Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress

Carter, H.H., Gong, P., Kirk, R.W., Eshaghian, S., Atkinson, C.L., Sampson, David, Green, D.J. and Mclaughlin, R.A. (2016) Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress Journal of Applied Physiology, 121 (4). pp. 965-972.

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Abstract

There are limited imaging technologies available that can accurately assess or provide surrogate markers of the in vivo cutaneous microvessel network in humans. In this study, we establish the use of optical coherence tomography (OCT) as a novel imaging technique to assess acute changes in cutaneous microvessel area density and diameter in humans. OCT speckle decorrelation images of the skin on the ventral side of the forearm up to a depth of 500 μm were obtained prior to and following 20-25 min of lower limb heating in eight healthy men [30.3 ± 7.6 (SD) yr]. Skin red blood cell flux was also collected using laser Doppler flowmetry probes immediately adjacent to the OCT skin sites, along with skin temperature. OCT speckle decorrelation images were obtained at both baseline and heating time points. Forearm skin flux increased significantly (0.20 ± 0.15 to 1.75 ± 0.38 cutaneous vascular conductance, P < 0.01), along with forearm skin temperature (32.0 ± 1.2 to 34.3 ± 1.0°C, P < 0.01). Quantitative differences in the automated calculation of vascular area densities (26 ± 9 to 49 ± 19%, P < 0.01) and individual microvessel diameters (68 ± 17 to 105 ± 25 μm, P < 0.01) were evident following the heating session. This is the first in vivo within-subject assessment of acute changes in the cutaneous microvasculature in response to heating in humans and highlights the use of OCT as an exciting new imaging approach for skin physiology and clinical research.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Carter, H.H.
Gong, P.
Kirk, R.W.
Eshaghian, S.
Atkinson, C.L.
Sampson, Davidd.sampson@surrey.ac.uk
Green, D.J.
Mclaughlin, R.A.
Date : 2016
DOI : 10.1152/japplphysiol.00918.2015
Uncontrolled Keywords : Laser Doppler, Optical coherence tomography, Skin microvessels, adult, anatomy and histology, diagnostic imaging, female, functions of the skin and its appendages, heat shock response, heat tolerance, human, microvasculature, optical coherence tomography, physiology, procedures, reproducibility, sensitivity and specificity, skin, vascularization, Adult, Female, Heat-Shock Response, Humans, Microvessels, Reproducibility of Results, Sensitivity and Specificity, Skin, Skin Physiological Phenomena, Thermotolerance, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 04 Jun 2018 09:01
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846756

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