In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

Gong, P., Es'haghian, S., Harms, K.-A., Murray, A., Rea, S., Wood, F.M., Sampson, David and McLaughlin, R.A. (2016) In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography Biomedical Optics Express, 7 (12). pp. 4886-4898.

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Abstract

We present an automated, label-free method for lymphangiography of cutaneous lymphatic vessels in humans in vivo using optical coherence tomography (OCT). This method corrects for the variation in OCT signal due to the confocal function and sensitivity fall-off of a spectral-domain OCT system and utilizes a single-scattering model to compensate for A-scan signal attenuation to enable reliable thresholding of lymphatic vessels. A segment-joining algorithm is then incorporated into the method to mitigate partial-volume effects with small vessels. The lymphatic vessel images are augmented with images of the blood vessel network, acquired from the speckle decorrelation with additional weighting to differentiate blood vessels from the observed high decorrelation in lymphatic vessels. We demonstrate the method with longitudinal scans of human burn scar patients undergoing ablative fractional laser treatment, showing the visualization of the cutaneous lymphatic and blood vessel networks.

Item Type:	Article
Divisions :	Faculty of Engineering and Physical Sciences Faculty of Health and Medical Sciences
Authors :	Name Email ORCID Gong, P. Es'haghian, S. Harms, K.-A. Murray, A. Rea, S. Wood, F.M. Sampson, David d.sampson@surrey.ac.uk McLaughlin, R.A.
Date :	2016
DOI :	10.1364/BOE.7.004886
Uncontrolled Keywords :	Image processing, Medical and biological imaging, Optical coherence tomography, Optical coherence tomography, Angiography, Image processing, Medical imaging, Optical data processing, Optical tomography, Patient treatment, Sensitivity analysis, Tomography, De correlations, Lymphatic vessels, Medical and biological imaging, Partial volume effect, Single-scattering model, Speckle decorrelation, Spectral domain OCT, Vessel networks, Blood vessels, A scan, adult, Article, burn scar, case report, diagnostic imaging, human, image processing, low level laser therapy, lymph vessel, lymphangiography, male, microvasculature, optical coherence tomography, refraction index
Depositing User :	Maria Rodriguez-Marquez
Date Deposited :	04 Jun 2018 09:26
Last Modified :	19 Sep 2018 11:32
URI:	http://epubs.surrey.ac.uk/id/eprint/846753

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