Optical coherence elastography for cellular-scale stiffness imaging of mouse aorta

Wijesinghe, P., Johansen, N.J., Curatolo, A., Sampson, David, Ganss, R. and Kennedy, B.F. (2017) Optical coherence elastography for cellular-scale stiffness imaging of mouse aorta

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Abstract

We have developed a high-resolution optical coherence elastography system capable of estimating Young’s modulus in tissue volumes with an isotropic resolution of 15 μm over a 1 mm lateral field of view and a 100 μm axial depth of field. We demonstrate our technique on healthy and hypertensive, freshly excised and intact mouse aortas. Our technique has the capacity to delineate the individual mechanics of elastic lamellae and vascular smooth muscle. Further, we observe global and regional vascular stiffening in hypertensive aortas, and note the presence of local micro-mechanical signatures, characteristic of fibrous and lipid-rich regions.

Item Type:	Conference or Workshop Item (UNSPECIFIED)
Divisions :	Faculty of Engineering and Physical Sciences Faculty of Health and Medical Sciences
Authors :	Name Email ORCID Wijesinghe, P. Johansen, N.J. Curatolo, A. Sampson, David d.sampson@surrey.ac.uk Ganss, R. Kennedy, B.F.
Date :	2017
DOI :	10.1117/12.2269903
Uncontrolled Keywords :	Elastic moduli, Mammals, Photonics, Depth of field, Field of views, High resolution, Intact mice, Isotropic resolution, Micro-mechanical, Optical coherence elastography, Vascular smooth muscles, Medical imaging
Depositing User :	Maria Rodriguez-Marquez
Date Deposited :	04 Jun 2018 08:51
Last Modified :	19 Sep 2018 11:32
URI:	http://epubs.surrey.ac.uk/id/eprint/846750

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