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Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

Fang, Q., Frewer, L., Wijesinghe, P., Allen, W.M., Chin, L., Hamzah, J., Sampson, David, Curatolo, A. and Ennedy, B.F.K. (2017) Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces Optics Letters, 42 (7). pp. 1233-1236.

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Abstract

Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Fang, Q.
Frewer, L.
Wijesinghe, P.
Allen, W.M.
Chin, L.
Hamzah, J.
Sampson, Davidd.sampson@surrey.ac.uk
Curatolo, A.
Ennedy, B.F.K.
Date : 2017
DOI : 10.1364/OL.42.001233
Uncontrolled Keywords : Interferometers, Silicones, Tissue, Breast conserving surgery, Clinical translation, Optical coherence elastography, Path length difference, Simultaneous acquisition, Spectral detection, Threedimensional (3-d), Time sensitive applications, Medical imaging, animal, cytology, diagnostic imaging, elastography, imaging phantom, liver, mouse, optical coherence tomography, procedures, three dimensional imaging, time factor, Animals, Elasticity Imaging Techniques, Imaging, Three-Dimensional, Liver, Mice, Phantoms, Imaging, Time Factors, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 04 Jun 2018 08:09
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846740

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