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Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment

Es'haghian, S., Gong, P., Chin, L., Harms, K.-A., Murray, A., Rea, S., Kennedy, B.F., Wood, F.M., Sampson, David and McLaughlin, R.A. (2017) Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment Journal of Biophotonics, 10 (4). pp. 511-522.

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Abstract

We demonstrate the use of the near-infrared attenuation coefficient, measured using optical coherence tomography (OCT), in longitudinal assessment of hypertrophic burn scars undergoing fractional laser treatment. The measurement method incorporates blood vessel detection by speckle decorrelation and masking, and a robust regression estimator to produce 2D en face parametric images of the attenuation coefficient of the dermis. Through reliable co-location of the field of view across pre- and post-treatment imaging sessions, the study was able to quantify changes in the attenuation coefficient of the dermis over a period of ~20 weeks in seven patients. Minimal variation was observed in the mean attenuation coefficient of normal skin and control (untreated) mature scars, as expected. However, a significant decrease (13 ± 5%, mean ± standard deviation) was observed in the treated mature scars, resulting in a greater distinction from normal skin in response to localized damage from the laser treatment. By contrast, we observed an increase in the mean attenuation coefficient of treated (31 ± 27%) and control (27 ± 20%) immature scars, with numerical values incrementally approaching normal skin as the healing progressed. This pilot study supports conducting a more extensive investigation of OCT attenuation imaging for quantitative longitudinal monitoring of scars. (Figure presented.) En face 2D OCT attenuation coefficient map of a treated immature scar derived from the pre-treatment (top) and the post-treatment (bottom) scans. (Vasculature (black) is masked out.) The scale bars are 0.5 mm.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Es'haghian, S.
Gong, P.
Chin, L.
Harms, K.-A.
Murray, A.
Rea, S.
Kennedy, B.F.
Wood, F.M.
Sampson, Davidd.sampson@surrey.ac.uk
McLaughlin, R.A.
Date : 2017
DOI : 10.1002/jbio.201500342
Uncontrolled Keywords : ablative fractional laser treatment, attenuation coefficient, hypertrophic burn scars, optical attenuation, optical coherence tomography, scar assessment, speckle decorrelation, vasculature, Blood vessels, Electromagnetic wave attenuation, Infrared devices, Patient treatment, Speckle, Tomography, Attenuation coefficient, Burn scar, Laser treatment, Optical attenuation, Scar assessment, Speckle decorrelation, Vasculature, Optical tomography, carbon dioxide, adult, burn, Cicatrix, Hypertrophic, complication, diagnostic imaging, feasibility study, female, human, laser, longitudinal study, low level laser therapy, male, middle aged, optical coherence tomography, pilot study, time factor, treatment outcome, young adult, Adult, Burns, Carbon Dioxide, Cicatrix, Hypertrophic, Feasibility Studies, Female, Humans, Laser Therapy, Lasers, Longitudinal Studies, Male, Middle Aged, Pilot Projects, Time Factors, Tomography, Optical Coherence, Treatment Outcome, Young Adult
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 04 Jun 2018 08:01
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846739

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