Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography
Chin, L., Latham, B., Saunders, C.M., Sampson, David and Kennedy, B.F. (2017) Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography Journal of Biophotonics, 10 (5). pp. 690-700.
Full text not available from this repository.Abstract
Surgical treatment of breast cancer aims to identify and remove all malignant tissue. Intraoperative assessment of tumor margins is, however, not exact; thus, re-excision is frequently needed, or excess normal tissue is removed. Imaging methods applicable intraoperatively could help to reduce re-excision rates whilst minimizing removal of excess healthy tissue. Optical coherence elastography (OCE) has been proposed for use in breast-conserving surgery; however, intraoperative interpretation of complex OCE images may prove challenging. Observations of breast cancer on multiple length scales, by OCE, ultrasound elastography, and atomic force microscopy, have shown an increase in the mechanical heterogeneity of malignant breast tumors compared to normal breast tissue. In this study, a micro-scale mechanical heterogeneity index is introduced and used to form heterogeneity maps from OCE scans of 10 ex vivo human breast tissue samples. Through comparison of OCE, optical coherence tomography images, and corresponding histology, malignant tissue is shown to possess a higher heterogeneity index than benign tissue. The heterogeneity map simplifies the contrast between tumor and normal stroma in breast tissue, facilitating the rapid identification of possible areas of malignancy, which is an important step towards intraoperative margin assessment using OCE. (Figure presented.).
Item Type: | Article | ||||||||||||||||||
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Divisions : |
Faculty of Engineering and Physical Sciences Faculty of Health and Medical Sciences |
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Authors : |
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Date : | 2017 | ||||||||||||||||||
DOI : | 10.1002/jbio.201600092 | ||||||||||||||||||
Uncontrolled Keywords : | breast cancer, mechanical heterogeneity, optical coherence elastography, optical coherence tomography, signal processing, tumor margins, visualization, Atomic force microscopy, Diseases, Flow visualization, Optical tomography, Signal processing, Surgery, Tissue, Tomography, Tumors, Breast Cancer, Breast conserving surgery, Human breast tissue, Mechanical heterogeneity, Micro-scale heterogeneity, Optical coherence elastography, Rapid identification, Ultrasound elastography, Medical imaging, breast, breast tumor, diagnostic imaging, elastography, female, human, optical coherence tomography, Breast, Breast Neoplasms, Elasticity Imaging Techniques, Female, Humans, Tomography, Optical Coherence | ||||||||||||||||||
Depositing User : | Maria Rodriguez-Marquez | ||||||||||||||||||
Date Deposited : | 04 Jun 2018 07:49 | ||||||||||||||||||
Last Modified : | 19 Sep 2018 11:32 | ||||||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/846736 |
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