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Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial

Istas, Geoffrey, Feliciano, Rodrigo P., Weber, Timon, Garcia-Villalba, Rocio, Tomas-Barberan, Francisco, Heiss, Christian and Rodriguez-Mateos, Ana (2018) Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial Archives of Biochemistry and Biophysics, 651. pp. 43-51.

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Abstract

Raspberries are a rich source of ellagitannins and anthocyanins. The aim of this work was to investigate whether raspberry consumption can improve vascular function and to understand which phenolic metabolites may be responsible for the effects. A 3 arm double-blind randomized controlled crossover human intervention trial was conducted in 10 healthy males. Flow-mediated dilation (FMD) was measured at baseline, 2 h, and 24 h post-consumption of 200 g and 400 g of red raspberries containing 201 or 403 mg of total (poly)phenols, or a matched control drink. Raspberry (poly)phenol metabolites were analyzed in plasma and urine by UPLC-QTOF mass spectrometry using authentic standards. Significant improvements in FMD were observed at 2 h (1.6% (95%CI 1.2, 1.9) and 1.2% (95% CI 0.8, 1.5)) and 24 h (1.0% (95% CI 0.6, 1.2) and 0.7% (95%CI 0.2, 0.9)) post-consumption of the 200 and 400 g raspberry drinks as compared to control, respectively. Plasma ellagic acid, urolithin A-3-glucuronide and urolithin A-sulfate correlated with the improvements in FMD at 2 and 24 h post consumption, respectively. Consumption of dietary achievable amounts of red raspberries acutely improves endothelial function up to 24 h and ellagitannins may be responsible for the observed effect.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Istas, Geoffrey
Feliciano, Rodrigo P.
Weber, Timon
Garcia-Villalba, Rocio
Tomas-Barberan, Francisco
Heiss, Christianc.heiss@surrey.ac.uk
Rodriguez-Mateos, Ana
Date : 24 May 2018
DOI : 10.1016/j.abb.2018.05.016
Copyright Disclaimer : © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
Uncontrolled Keywords : Raspberries; Endothelial function; (Poly)phenols; Ellagittanins; Urolithins
Depositing User : Clive Harris
Date Deposited : 31 May 2018 07:42
Last Modified : 25 May 2019 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/846541

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