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Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents

Seibt, Julie, Richard, C, Sigl-Glöckner, J, Takahashi, N, Kaplan, D, Doron, G, de Limoges, D, Bocklisch, C and Larkum, M (2017) Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents Nature Communications, 8, 684.

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Abstract

How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep. Here, we report that calcium activity in populations of neocortical dendrites is increased and synchronised during oscillations in the spindle range in naturally sleeping rodents. Remarkably, the same relationship is not found in cell bodies of the same neurons and throughout the cortical column. Spindles during sleep have been suggested to be important for brain development and plasticity. Our results provide evidence for a physiological link of spindles in the cortex specific to dendrites, the main site of synaptic plasticity.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Seibt, Juliej.seibt@surrey.ac.uk
Richard, C
Sigl-Glöckner, J
Takahashi, N
Kaplan, D
Doron, G
de Limoges, D
Bocklisch, C
Larkum, M
Date : 25 September 2017
DOI : 10.1038/s41467-017-00735-w
Copyright Disclaimer : © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Depositing User : Melanie Hughes
Date Deposited : 16 May 2018 11:01
Last Modified : 16 Jan 2019 19:09
URI: http://epubs.surrey.ac.uk/id/eprint/846426

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