University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Emergence of Nonfalciparum Plasmodium Infection Despite Regular Artemisinin Combination Therapy in an 18-Month Longitudinal Study of Ugandan Children and Their Mothers

Betson, Martha, Clifford, Sarah, Stanton, Michelle, Kabatereine, Narcis B and Stothard, J Russell (2018) Emergence of Nonfalciparum Plasmodium Infection Despite Regular Artemisinin Combination Therapy in an 18-Month Longitudinal Study of Ugandan Children and Their Mothers The Journal of Infectious Diseases, 217 (7). pp. 1099-1109.

[img]
Preview
Text
Emergence of Nonfalciparum Plasmodium Infection.pdf - Version of Record
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

As part of a longitudinal cohort investigation of intestinal schistosomiasis and malaria in Ugandan children and their mothers on the shorelines of Lakes Victoria and Albert, we documented risk factors and morbidity associated with nonfalciparum Plasmodium infections and the longitudinal dynamics of Plasmodium species in children. Host age, household location, and Plasmodium falciparum infection were strongly associated with nonfalciparum Plasmodium infections, and Plasmodium malariae infection was associated with splenomegaly. Despite regular artemisinin combination therapy treatment, there was a 3-fold rise in P. malariae prevalence, which was not accountable for by increasing age of the child. Worryingly, our findings reveal the consistent emergence of nonfalciparum infections in children, highlighting the complex dynamics underlying multispecies infections here. Given the growing body of evidence that nonfalciparum malaria infections cause significant morbidity, we encourage better surveillance for nonfalciparum Plasmodium infections, particularly in children, with more sensitive DNA detection methods and improved field-based diagnostics.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Betson, Martham.betson@surrey.ac.uk
Clifford, Sarah
Stanton, Michelle
Kabatereine, Narcis B
Stothard, J Russell
Date : 6 January 2018
DOI : 10.1093/infdis/jix686
Copyright Disclaimer : © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : Child; Parasites; Combined modality therapy; Malaria; Mothers; Plasmodium falciparum; Plasmodium malariae; Infection; Artemisinine; Plasmodium ovale
Depositing User : Clive Harris
Date Deposited : 10 May 2018 09:30
Last Modified : 16 Jan 2019 19:09
URI: http://epubs.surrey.ac.uk/id/eprint/846390

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800