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Melanomacrophage functions in the liver of the caecilian Siphonops annulatus

Gutierre, Robson Campos, Jared, Carlos, Antoniazzi, Marta Maria, Coppi, Antonio Augusto and Egami, Mizue Imoto (2017) Melanomacrophage functions in the liver of the caecilian Siphonops annulatus Journal of Anatomy, 232 (3). pp. 497-508.

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Abstract

Melanomacrophages are phagocytes that synthesize melanin. They are found in the liver and spleen of ectothermic vertebrates, and in the kidney of fish. In agnathan and elasmobranch fish, melanomacrophages are seen as isolated cells, and forming clusters in all the other vertebrates. The natural phagocytic activity of melanomacrophages is poorly characterized, as most of the research works have focused on induced phagocytic activity only. Furthermore, little is known about amphibian melanomacrophages, mainly about those in caecilians – wormlike amphibians in the order of Gymnophiona, which is the least known group of terrestrial vertebrates. The present research work aimed at the structure and function of hepatic melanomacrophages of Siphonops annulatus, a species largely found in South America. We identified the role of these cells in the control of circulating basophils (pro‐melanogenic cells), in the turnover of liver collagen stroma and in the hemocatheresis, interrelated physiological mechanisms.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Gutierre, Robson Campos
Jared, Carlos
Antoniazzi, Marta Maria
Coppi, Antonio Augustoa.coppi@surrey.ac.uk
Egami, Mizue Imoto
Date : 4 December 2017
DOI : 10.1111/joa.12757
Copyright Disclaimer : © 2017 Anatomical Society
Depositing User : Clive Harris
Date Deposited : 03 May 2018 13:07
Last Modified : 16 Jan 2019 19:09
URI: http://epubs.surrey.ac.uk/id/eprint/846346

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