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Adipokines and inflammation: is it a question of weight?

Francisco, Vera, Pino, Jesus, Gonzalez-Gay, Miguel Angel, Mera, Antonio, Lago, Francisca, Gómez, Rodolfo, Mobasheri, Ali and Gualillo, Oreste (2018) Adipokines and inflammation: is it a question of weight? British Journal of Pharmacology, 175 (10). pp. 1569-1579.

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Obesity has reached epidemic proportions in the Western society and is increasing in the developing world. It is considered as one of the major contributors to the global burden of disability and chronic diseases, including autoimmune, inflammatory and degenerative diseases. Research conducted on obesity and its complications over the last two decades has transformed the outdated concept of white adipose tissue (WAT) merely serving as an energy depot. WAT is now recognized as an active and inflammatory organ capable of producing a wide variety of factors known as adipokines. These molecules participate through endocrine, paracrine, autocrine or juxtacrine crosstalk mechanisms in a great variety of physiological or pathophysiological processes, regulating food intake, insulin sensitivity, immunity and inflammation. Although initially restricted to metabolic activities (regulation of glucose and lipid metabolism), adipokines currently represent a new family of proteins that can be considered key players in the complex network of soluble mediators involved in the pathophysiology of immune/inflammatory diseases. However, the complexity of the adipokine network in the pathogenesis and progression of inflammatory diseases has posed, since the beginning, the important question of whether it may be possible to target the mechanism(s) by which adipokines contribute to disease selectively without suppressing their physiological functions. Here, we explore in depth the most recent findings concerning the involvement of adipokines in inflammation and immune responses, in particular in rheumatic, inflammatory and degenerative diseases. We also highlight several possible strategies for therapeutic development and propose that adipokines and their signalling pathways may represent innovative therapeutic strategies for inflammatory disorders.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
Francisco, Vera
Pino, Jesus
Gonzalez-Gay, Miguel Angel
Mera, Antonio
Lago, Francisca
Gómez, Rodolfo
Gualillo, Oreste
Date : 27 February 2018
DOI : 10.1111/bph.14181
Copyright Disclaimer : © 2018 The British Pharmacological Society
Depositing User : Clive Harris
Date Deposited : 26 Apr 2018 09:32
Last Modified : 16 Jan 2019 19:09

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