Attire: albumin to prevent infection in chronic liver failure
China, L, Fullerton, J, George, M, Skene, S, Shabir, Z, Gilroy, D and O'Brien, A (2015) Attire: albumin to prevent infection in chronic liver failure JOURNAL OF HEPATOLOGY, 62(S2). ppS853-S853.
Full text not available from this repository.Abstract
Background and Aims: Patients with cirrhosis are at a greatly increased risk of severe bacterial infection with survival directly related to extra-hepatic organ dysfunction. A defective innate immune response is considered to underlie this risk. There is however no medical strategy to restore immune competence in these patients. Elevated circulating Prostaglandin E2 (PGE2) levels contribute to immune suppression in acutely decompensated (AD) cirrhosis. PGE2 is more bioavailable because of decreased serum albumin levels in AD patients as albumin binds PGE2. The binding capacity of endogenous albumin is also known to be defective in cirrhosis. Human Albumin Solution (HAS), a safe and common intervention, could thus be repurposed as an immune restorative drug in AD patients. The primary aim of ATTIRE is to determine if raising serum albumin to >30 g/L in patients with decompensated cirrhosis will decrease rates of infection, extra hepatic organ dysfunction and death.
Item Type: | Article | ||||||||||||||||||||||||
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Divisions : |
Faculty of Health and Medical Sciences > Surrey Clinical Research Centre Faculty of Health and Medical Sciences |
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Date : | 10 June 2015 | ||||||||||||||||||||||||
DOI : | 10.1016/S0168-8278(15)31506-3 | ||||||||||||||||||||||||
Copyright Disclaimer : | Copyright © 2015 European Association for the Study of the Liver | ||||||||||||||||||||||||
Depositing User : | Diane Maxfield | ||||||||||||||||||||||||
Date Deposited : | 24 Apr 2018 11:35 | ||||||||||||||||||||||||
Last Modified : | 27 Sep 2019 14:20 | ||||||||||||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/846296 |
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