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Attire: albumin to prevent infection in chronic liver failure

Skene, Simon, China, L, Fullerton, J, George, M, Shabir, Z, Gilroy, D and O'Brien, A (2015) Attire: albumin to prevent infection in chronic liver failure JOURNAL OF HEPATOLOGY, 62(S2). ppS853-S853.

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Abstract

Background and Aims: Patients with cirrhosis are at a greatly increased risk of severe bacterial infection with survival directly related to extra-hepatic organ dysfunction. A defective innate immune response is considered to underlie this risk. There is however no medical strategy to restore immune competence in these patients. Elevated circulating Prostaglandin E2 (PGE2) levels contribute to immune suppression in acutely decompensated (AD) cirrhosis. PGE2 is more bioavailable because of decreased serum albumin levels in AD patients as albumin binds PGE2. The binding capacity of endogenous albumin is also known to be defective in cirrhosis. Human Albumin Solution (HAS), a safe and common intervention, could thus be repurposed as an immune restorative drug in AD patients. The primary aim of ATTIRE is to determine if raising serum albumin to >30 g/L in patients with decompensated cirrhosis will decrease rates of infection, extra hepatic organ dysfunction and death.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > Surrey Clinical Research Centre
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Skene, Simons.skene@surrey.ac.uk
China, L
Fullerton, J
George, M
Shabir, Z
Gilroy, D
O'Brien, A
Date : 10 June 2015
DOI : 10.1016/S0168-8278(15)31506-3
Copyright Disclaimer : Copyright © 2015 European Association for the Study of the Liver
Depositing User : Diane Maxfield
Date Deposited : 24 Apr 2018 11:35
Last Modified : 16 Jan 2019 19:09
URI: http://epubs.surrey.ac.uk/id/eprint/846296

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