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The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine

Schwartz, J, Hemmink, J, Graham, Simon, Tchilian, E, Charleston, B, Hammer, S, Ho, C-S and Hammond, J (2018) The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine HLA, 92 (1). pp. 40-43.

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Abstract

The Babraham pig is a highly inbred breed first developed in the United Kingdom approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the major histocompatibility complex (MHC) region, but confirmation of homozygosity at the specific MHC loci was lacking. Using both direct sequencing and PCR‐based sequence‐specific typing, we confirm that Babraham pigs are essentially homozygous at their MHC loci and formalise their MHC haplotype as Hp‐55.6. This enhances the utility of the Babraham pig as a useful biomedical model for studies in which controlling for genetic variation is important.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Schwartz, J
Hemmink, J
Graham, Simons.graham@surrey.ac.uk
Tchilian, E
Charleston, B
Hammer, S
Ho, C-S
Hammond, J
Date : 23 April 2018
Funders : BBSRC
DOI : 10.1111/tan.13281
Copyright Disclaimer : © 2018 The Authors. HLA published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : genotyping, SSP typing , Sus scrofa , swine leukocyte antigen , SLA
Depositing User : Melanie Hughes
Date Deposited : 19 Apr 2018 08:24
Last Modified : 11 Jun 2019 14:21
URI: http://epubs.surrey.ac.uk/id/eprint/846263

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