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Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels

Carvalho Pereira, Andreia, Violante, Inês R., Mouga, Susana, Oliveira, Guiomar and Castelo-Branco, Miguel (2017) Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels Journal of Autism and Developmental Disorders, 48 (5). pp. 1467-1482.

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Abstract

The nature of neurochemical changes in autism spectrum disorder (ASD) remains controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high-functioning children and adolescents with ASD without associated comorbidities and fourteen controls. We observed reduced total N-acetylaspartate (tNAA) and total creatine, increased Glx/tNAA but unchanged glutamate + glutamine (Glx) and unchanged absolute or relative gamma-aminobutyric acid (GABA+) in the ASD group. Importantly, both smaller absolute and relative GABA+ levels were associated with worse communication skills and developmental delay scores assessed by the autism diagnostic interview—revised (ADI-R). We conclude that tNAA is reduced in the mPFC in ASD and that glutamatergic metabolism may be altered due to unbalanced Glx/tNAA. Moreover, GABA+ is related to autistic symptoms assessed by the ADI-R.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
NameEmailORCID
Carvalho Pereira, Andreia
Violante, Inês R.ines.violante@surrey.ac.uk
Mouga, Susana
Oliveira, Guiomar
Castelo-Branco, Miguel
Date : 24 November 2017
Identification Number : 10.1007/s10803-017-3406-8
Copyright Disclaimer : © Springer Science+Business Media, LLC, part of Springer Nature 2017
Uncontrolled Keywords : Autism spectrum disorder; N-acetylaspartate; Gamma-aminobutyric acid; Glutamate + glutamine; Creatine; Autism diagnostic interview—revised
Depositing User : Clive Harris
Date Deposited : 12 Apr 2018 07:56
Last Modified : 12 Apr 2018 07:56
URI: http://epubs.surrey.ac.uk/id/eprint/846191

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