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Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis

Datta, Gourab, Violante, Ines R, Scott, Gregory, Zimmerman, Karl, Santos-Ribeiro, Andre, Rabiner, Eugenii A, Gunn, Roger N, Malik, Omar, Ciccarelli, Olga, Nicholas, Richard and Matthews, Paul M (2016) Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis Multiple Sclerosis Journal, 23 (11). pp. 1469-1478.

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Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.doc - Accepted version Manuscript

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Abstract

Background: Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this.

Objective: To explore the in vivo relationships between MRS and PET [11C]PBR28 in MS over a range of brain inflammatory burden. Methods: A total of 23 patients were studied. TSPO PET imaging with [11C]PBR28, single voxel MRS and conventional magnetic resonance imaging (MRI) sequences were undertaken. Disability was assessed by Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC).

Results: [11C]PBR28 uptake and [myo-inositol] were not associated. When the whole cohort was stratified by higher [11C]PBR28 inflammatory burden, [myo-inositol] was positively correlated to [11C]PBR28 uptake (Spearman’s ρ=0.685, p=0.014). Moderate correlations were found between [11C]PBR28 uptake and both MRS creatine normalised N-acetyl aspartate (NAA) concentration and grey matter volume. MSFC was correlated with grey matter volume (ρ=0.535, p=0.009). There were no associations between other imaging or clinical measures.

Conclusion: MRS [myo-inositol] and PET [11C]PBR28 measure independent inflammatory processes which may be more commonly found together with more severe inflammatory disease. Microglial activation measured by [11C]PBR28 uptake was associated with loss of neuronal integrity and grey matter atrophy

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
NameEmailORCID
Datta, Gourab
Violante, Ines Rines.violante@surrey.ac.uk
Scott, Gregory
Zimmerman, Karl
Santos-Ribeiro, Andre
Rabiner, Eugenii A
Gunn, Roger N
Malik, Omar
Ciccarelli, Olga
Nicholas, Richard
Matthews, Paul M
Date : 7 December 2016
Identification Number : 10.1177/1352458516681504
Copyright Disclaimer : © The Author(s), 2016. Reprints and permissions: http://www.sagepub.co.uk/ journalsPermissions.nav
Uncontrolled Keywords : Multiple sclerosis; Glia; Biomarkers; MRI
Depositing User : Clive Harris
Date Deposited : 12 Apr 2018 07:44
Last Modified : 03 Aug 2018 07:40
URI: http://epubs.surrey.ac.uk/id/eprint/846190

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