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Proton Beam Therapy – the Challenges of Delivering High-quality Evidence of Clinical Benefit

Amos, R, Bulbeck, H, Burnet, N, Crellin, A, Eaton, D, Evans, Philip, Hall, E, Hawkins, M, Mackay, R, Kirkby, K , Sharma, R and Sebag-Montefiore, D (2018) Proton Beam Therapy – the Challenges of Delivering High-quality Evidence of Clinical Benefit Clinical Oncology, 30 (5). pp. 280-284.

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The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
Amos, R
Bulbeck, H
Burnet, N
Crellin, A
Eaton, D
Hall, E
Hawkins, M
Mackay, R
Kirkby, K
Sharma, R
Sebag-Montefiore, D
Date : 15 March 2018
DOI : 10.1016/j.clon.2018.02.031
Copyright Disclaimer : © 2018 Published by Elsevier Ltd on behalf of The Royal College of Radiologists. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Uncontrolled Keywords : Proton beam therapy, external beam radiotherapy, clinical trials
Depositing User : Melanie Hughes
Date Deposited : 10 Apr 2018 10:32
Last Modified : 15 Mar 2019 02:08

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