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Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non-alcoholic fatty liver disease

Gibson, Philippa S., Quaglia, Alberto, Dhawan, Anil, Wu, Huihai, Lanham-New, Sue, Hart, Kath, Fitzpatrick, Emer and Moore, J. Bernadette (2018) Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non-alcoholic fatty liver disease Pediatric Obesity.

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Abstract

Background: Vitamin D deficiency has been associated with non-alcoholic fatty liver disease (NAFLD). However, the role of polymorphisms determining vitamin D status remains unknown. Objectives: To determine in UK children with biopsy-proven NAFLD: (i) vitamin D status throughout a 12-month period; (ii) interactions between key vitamin D-related genetic variants (NADSYN1/DHCR7, VDR, GC, CYP2R1) and disease severity. Methods: In 103 pediatric patients with NAFLD, serum 25-hydroxyvitamin D (25OHD) levels and genotypes were determined contemporaneously to liver biopsy and examined in relation to NAFLD activity score and fibrosis stage. Results: Only 19.2% of children had adequate vitamin D status; most had mean 25OHD levels considered deficient (<25nmol/l, 25.5%) or insufficient (<50nmol/l, 55.3%). Patients had significantly lower 25OHD levels in winter months (95%CI: 22.7-31.2nmol/l) when compared to spring (30.5-42.1nmol/l; P=0.0089), summer (36.3-47.2nmol/l; P<0.0001) and autumn (34.2-47.5nmol/l; P=0.0003). Polymorphisms in the NADSYN1/DHCR7 (rs3829251, rs12785878), and VDR (rs2228570) genes were independently associated with increased steatosis; while a GC variant (rs4588) was associated with increased inflammation in liver biopsies. Conclusions: Children with NAFLD in the UK have particularly low winter vitamin D status; with vitamin D insufficiency prevalent throughout the year. Polymorphisms in the vitamin D metabolic pathway are associated with histological severity of pediatric NAFLD.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Gibson, Philippa S.p.s.gibson@surrey.ac.uk
Quaglia, Alberto
Dhawan, Anil
Wu, HuihaiH.Wu@surrey.ac.uk
Lanham-New, SueS.Lanham-New@surrey.ac.uk
Hart, KathK.Hart@surrey.ac.uk
Fitzpatrick, Emer
Moore, J. BernadetteJ.B.Moore@surrey.ac.uk
Date : 2018
Copyright Disclaimer : © 2018 World Obesity Federation
Uncontrolled Keywords : Non-alcoholic fatty liver disease; Pediatric; Vitamin D; 25OHD; Genotype; Polymorphism
Related URLs :
Depositing User : Clive Harris
Date Deposited : 09 Apr 2018 09:04
Last Modified : 09 Apr 2018 09:04
URI: http://epubs.surrey.ac.uk/id/eprint/846146

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