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Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non-alcoholic fatty liver disease

Gibson, Philippa S., Quaglia, Alberto, Dhawan, Anil, Wu, Huihai, Lanham-New, Sue, Hart, Kath, Fitzpatrick, Emer and Moore, J. Bernadette (2018) Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non-alcoholic fatty liver disease Pediatric Obesity.

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Abstract

Background: Vitamin D deficiency has been associated with non-alcoholic fatty liver disease (NAFLD). However, the role of polymorphisms determining vitamin D status remains unknown. Objectives: To determine in UK children with biopsy-proven NAFLD: (i) vitamin D status throughout a 12-month period; (ii) interactions between key vitamin D-related genetic variants (NADSYN1/DHCR7, VDR, GC, CYP2R1) and disease severity. Methods: In 103 pediatric patients with NAFLD, serum 25-hydroxyvitamin D (25OHD) levels and genotypes were determined contemporaneously to liver biopsy and examined in relation to NAFLD activity score and fibrosis stage. Results: Only 19.2% of children had adequate vitamin D status; most had mean 25OHD levels considered deficient (<25nmol/l, 25.5%) or insufficient (<50nmol/l, 55.3%). Patients had significantly lower 25OHD levels in winter months (95%CI: 22.7-31.2nmol/l) when compared to spring (30.5-42.1nmol/l; P=0.0089), summer (36.3-47.2nmol/l; P<0.0001) and autumn (34.2-47.5nmol/l; P=0.0003). Polymorphisms in the NADSYN1/DHCR7 (rs3829251, rs12785878), and VDR (rs2228570) genes were independently associated with increased steatosis; while a GC variant (rs4588) was associated with increased inflammation in liver biopsies. Conclusions: Children with NAFLD in the UK have particularly low winter vitamin D status; with vitamin D insufficiency prevalent throughout the year. Polymorphisms in the vitamin D metabolic pathway are associated with histological severity of pediatric NAFLD.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Gibson, Philippa S.p.s.gibson@surrey.ac.uk
Quaglia, Alberto
Dhawan, Anil
Wu, HuihaiH.Wu@surrey.ac.uk
Lanham-New, SueS.Lanham-New@surrey.ac.uk
Hart, KathK.Hart@surrey.ac.uk
Fitzpatrick, Emer
Moore, J. BernadetteJ.B.Moore@surrey.ac.uk
Date : 14 May 2018
Identification Number : 10.1111/ijpo.12293
Copyright Disclaimer : © 2018 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Uncontrolled Keywords : Non-alcoholic fatty liver disease; Pediatric; Vitamin D; 25OHD; Genotype; Polymorphism
Related URLs :
Depositing User : Clive Harris
Date Deposited : 09 Apr 2018 09:04
Last Modified : 29 May 2018 10:46
URI: http://epubs.surrey.ac.uk/id/eprint/846146

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