University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Winter Cholecalciferol Supplementation at 51°N Has No Effect on Markers of Cardiometabolic Risk in Healthy Adolescents Aged 14-18 Years

Smith, Taryn J, Tripkovic, Laura, Hauger, Hanne, Damsgaard, Camilla T, Mølgaard, Christian, Lanham-New, Susan and Hart, Kathryn H (2018) Winter Cholecalciferol Supplementation at 51°N Has No Effect on Markers of Cardiometabolic Risk in Healthy Adolescents Aged 14-18 Years The Journal of Nutrition, 148 (8). pp. 1269-1275.

Winter Cholecalciferol Supplementation.pdf - Accepted version Manuscript

Download (575kB) | Preview


Background: Epidemiological studies have supported inverse associations between low serum 25-hydroxyvitamin D [25(OH)D] and cardiometabolic risk markers, but few randomized trials have investigated the effect of vitamin D supplementation on these markers in adolescents.

Objective: The objective of this study was to investigate the effect of winter-time cholecalciferol (vitamin D3) supplementation on cardiometabolic risk markers in white, healthy 14-18 year-old adolescents in the UK (51°N) as part of the ODIN Project.

Methods: In a dose-response trial, 110 adolescents (15.9±1.4 years; 43% male; 81% normal weight) were randomly assigned to receive 0, 10 or 20 μg/day vitamin D3 for 20 weeks (October-March). Cardiometabolic risk markers including BMI-for-age z-score (BMIz), waist circumference, systolic and diastolic blood pressure, fasting plasma triglycerides, cholesterol (total, HDL, LDL and total:HDL) and glucose were measured at baseline and endpoint as secondary outcomes, together with serum 25(OH)D. Intervention effects were evaluated in linear regression models as between-group differences at endpoint, adjusted for the baseline value of the outcome variable and additionally for age, sex, Tanner stage, BMIz and baseline serum 25(OH)D.

Results: Mean±SD baseline serum 25(OH)D was 49.1±12.3 nmol/L and differed between groups at endpoint with concentrations of 30.7±8.6, 56.6±12.4 and 63.9±10.6 nmol/L in the 0, 10 and 20 μg/day groups respectively (P≤0.001). Vitamin D3 supplementation had no effect on any of the cardiometabolic risk markers (all P>0.05), except for lower HDL (-0.12 mmol/L, 95% CI -0.21, 0.04, P=0.003) and total cholesterol (-0.21 mmol/L, 95% CI -0.42, 0.00, P=0.05) in the 20 compared to the 10 μg/day group, which disappeared in the fully adjusted analysis (P=0.27 and P=0.30 respectively).

Conclusions: Supplementation with vitamin D3 at 10 and 20 μg/25 day, which increased serum 25(OH)D concentrations during the winter-time, had no effect on markers of cardiometabolic risk in healthy 14-18 year-old adolescents. This trial was registered at as NCT02150122.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Smith, Taryn J
Hauger, Hanne
Damsgaard, Camilla T
Mølgaard, Christian
Hart, Kathryn
Date : 15 June 2018
DOI : 10.1093/jn/nxy079
Copyright Disclaimer : © American Society for Nutrition 2018
Uncontrolled Keywords : Vitamin D; Adolescents; Cardiovascular risk factors; Randomized controlled trial
Related URLs :
Additional Information : Trial registered: Reg No. NCT02150122. This project was funded by the European Commission from the Seventh Framework Programme (FP7/2007-2013) under Grant Agreement 613977 for the ODIN Project (Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle; The vitamin D3 supplements and matching placebo tablets were provided by Oy Verman Ab.
Depositing User : Clive Harris
Date Deposited : 09 Apr 2018 08:11
Last Modified : 28 Mar 2019 02:08

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800