University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Torlinska, B, Bath, Sarah, Janjua, A, Boelaert, K and Chan, S-Y (2018) Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC) Nutrients, 10 (3).

[img]
Preview
Text
nutrients-10-00291-v2.pdf - Version of Record
Available under License Creative Commons Attribution.

Download (276kB) | Preview
[img] Text
ObstetricsProof_28Feb18.docx - Accepted version Manuscript
Available under License Creative Commons Attribution.

Download (142kB)

Abstract

Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild–to–moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss. The group was classified as mildly-to-moderately iodine deficient with a median urinary iodine concentration of 95.3 µg/L (IQR 57.0–153.0; median urinary iodine-to-creatinine ratio (UI/Creat) 124 µg/g, IQR 82-198). The likelihood of pregnancy/infant loss was not different across four UI/Creat groups (<50, 50–149, 150–250, >250 µg/g). The incidence of pre-eclampsia, non-proteinuric gestational hypertension, gestational diabetes, glycosuria, anaemia, post-partum haemorrhage, preterm delivery, mode of delivery, being small for gestational age, and large for gestational age did not differ significantly among UI/Creat groups, nor were there any significant differences in the median UI/Creat. We conclude that maternal iodine status was not associated with adverse pregnancy outcomes in a mildly-to-moderately iodine-deficient pregnant population. However, in view of the low number of women with pregnancy/infant loss in our study, further research is required.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Torlinska, B
Bath, Sarahs.bath@surrey.ac.uk
Janjua, A
Boelaert, K
Chan, S-Y
Date : 1 March 2018
Identification Number : 10.3390/nu10030291
Copyright Disclaimer : © 2018 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords : iodine; pregnancy; obstetric; UK; Avon Longitudinal Study of Parents and Children (ALSPAC)
Additional Information : (This article belongs to the Special Issue Iodine and Health throughout the Lifecourse)
Depositing User : Melanie Hughes
Date Deposited : 09 Mar 2018 15:48
Last Modified : 28 Mar 2018 15:55
URI: http://epubs.surrey.ac.uk/id/eprint/845979

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800