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Cardiac Potassium Channels: Physiological Insights for Targeted Therapy

Jeevaratnam, Kamalan, Chadda, K, Huang, C and Camm, A (2017) Cardiac Potassium Channels: Physiological Insights for Targeted Therapy Journal of Cardiovascular Pharmacology and Therapeutics, 23 (2). pp. 119-129.

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Abstract

The development of novel drugs specifically directed at the ion channels underlying particular features of cardiac action potential (AP) initiation, recovery, and refractoriness would contribute to an optimized approach to antiarrhythmic therapy that minimizes potential cardiac and extracardiac toxicity. Of these, Kþ channels contribute numerous and diverse currents with specific actions on different phases in the time course of AP repolarization. These features and their site-specific distribution make particular Kþ channel types attractive therapeutic targets for the development of pharmacological agents attempting antiarrhythmic therapy in conditions such as atrial fibrillation. However, progress in the development of such temporally and spatially selective antiarrhythmic drugs against particular ion channels has been relatively limited, particularly in view of our incomplete understanding of the complex physiological roles and interactions of the various ionic currents. This review summarizes the physiological properties of the main cardiac potassium channels and the way in which they modulate cardiac electrical activity and then critiques a number of available potential antiarrhythmic drugs directed at them.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Jeevaratnam, Kamalank.jeevaratnam@surrey.ac.uk
Chadda, K
Huang, C
Camm, A
Date : 25 September 2017
Identification Number : 10.1177/1074248417729880
Copyright Disclaimer : Copyright The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Uncontrolled Keywords : potassium channels, repolarization, physiological mechanisms, currents, ion channel, drug target
Depositing User : Melanie Hughes
Date Deposited : 27 Feb 2018 18:28
Last Modified : 30 May 2018 10:55
URI: http://epubs.surrey.ac.uk/id/eprint/845908

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