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Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: an individual patient data meta-analysis of 22 RCTs.

Kalter, J., Verdonck-de Leeuw, I.M., Sweegers, M.G., Aaronson, N.K., Jacobsen, P.B., Newton, R.U., Courneya, K.S., Aitken, J.F., Armes, Jo, Arving, C. , Boersma, L.J., Braamse, A.M., Brandberg, Y., Chambers, S.K., Dekker, J., Ell, K., Ferguson, R.J., Gielissen, M.F., Glimelius, B., Goedendorp, M.M., Graves, K.D., Heiney, S.P., Horne, R., Hunter, M.S., Johansson, B., Kimman, M.L., Knoop, H., Meneses, K., Northouse, L.L., Oldenburg, H.S., Prins, J.B., Savard, J., van Beurden, M., van den Berg, S.W., Brug, J. and Buffart, L.M. (2018) Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: an individual patient data meta-analysis of 22 RCTs. Psycho-Oncology.

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Abstract

Objective:
This individual patient data (IPD) meta-analysis aimed to evaluate the effects of psychosocial interventions (PSI) on quality of life (QoL), emotional function (EF) and social function (SF) in patients with cancer, and to study moderator effects of demographic, clinical, personal, and intervention-related characteristics.

Methods:
Relevant studies were identified via literature searches in four databases. We pooled IPD from 22 (n=4,217) of 61 eligible randomized controlled trials (RCTs). Linear mixed-effect model analyses were used to study intervention effects on the post-intervention values of QoL, EF, and SF (z-scores), adjusting for baseline values, age, and cancer type. We studied moderator effects by testing interactions with the intervention for demographic, clinical, personal, and intervention-related characteristics, and conducted subsequent stratified analyses for significant moderator variables.

Results:
PSI significantly improved QoL (β=0.14,95%CI=0.06;0.21), EF (β=0.13,95%CI=0.05;0.20), and SF (β=0.10,95%CI=0.03;0.18). Significant differences in effects of different types of PSI were found, with largest effects of psychotherapy. The effects of coping skills training (CST) were moderated by age, treatment type, and targeted interventions. Effects of psychotherapy on EF may be moderated by cancer type, but these analyses were based on two RCTs with small sample sizes of some cancer types.

Conclusions:
PSI significantly improved QoL, EF, and SF, with small overall effects. However, the effects differed by several demographic, clinical, personal, and intervention-related characteristics. Our study highlights the beneficial effects of CST in patients treated with chemotherapy, the importance of targeted interventions, and the need of developing interventions tailored to the specific needs of elderly patients.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Health Sciences
Authors :
NameEmailORCID
Kalter, J.
Verdonck-de Leeuw, I.M.
Sweegers, M.G.
Aaronson, N.K.
Jacobsen, P.B.
Newton, R.U.
Courneya, K.S.
Aitken, J.F.
Armes, Jojo.armes@surrey.ac.uk
Arving, C.
Boersma, L.J.
Braamse, A.M.
Brandberg, Y.
Chambers, S.K.
Dekker, J.
Ell, K.
Ferguson, R.J.
Gielissen, M.F.
Glimelius, B.
Goedendorp, M.M.
Graves, K.D.
Heiney, S.P.
Horne, R.
Hunter, M.S.
Johansson, B.
Kimman, M.L.
Knoop, H.
Meneses, K.
Northouse, L.L.
Oldenburg, H.S.
Prins, J.B.
Savard, J.
van Beurden, M.
van den Berg, S.W.
Brug, J.
Buffart, L.M.
Date : 23 January 2018
Identification Number : 10.1002/pon.4648
Copyright Disclaimer : Copyright © 2018 John Wiley & Sons, Ltd. This is the peer reviewed version of the following article: Kalter J, Verdonck-de Leeuw IM, Sweegers MG, et al. Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: an individual patient data meta-analysis of 22 RCTs. Psycho-Oncology. 2018. ...which has been published in final form at https://doi.org/10.1002/pon.4648. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords : Psychosocial care; Quality of life; Neoplasm; Individual patient data meta-analysis; Coping skills training; Psychotherapy
Depositing User : Clive Harris
Date Deposited : 02 Feb 2018 14:18
Last Modified : 14 Mar 2018 08:36
URI: http://epubs.surrey.ac.uk/id/eprint/845736

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