University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Targeting beta-cell preservation in the management of type 2 diabetes

Boughton, Charlotte K, Munro, Neil and Whyte, Martin (2017) Targeting beta-cell preservation in the management of type 2 diabetes British Journal of Diabetes, 17 (4). pp. 134-144.

[img] Text
Targeting beta-cell preservation in the management of type 2 diabetes.pdf - Version of Record
Restricted to Repository staff only

Download (2MB)

Abstract

Type 2 diabetes (T2D) is widely considered a chronic and progressive disease without cure. As beta-cell function progressively declines over time, blood glucose rises. Current management of T2D involves incremental introduction of dietary and drug therapies to achieve normoglycaemia. However, recent studies have demonstrated remission of T2D following bariatric surgery, very low calorie diet or intensive insulin therapy, raising the possibility that the declining beta-cell function in T2D may be arrested or even reversed. The point at which such interventions are introduced in the course of T2D is key for clinical benefit. Future treatment strategies should be revised to target early betacell preservation and thus disease remission. This article reviews the pathogenesis of beta-cell dysfunction and evidence for the clinical benefit of preserving beta-cell function in T2D, and discusses the evidence for beta-cell preservation of current glucose-lowering therapies with particular reference to their effect when initiated at the time of diagnosis of T2D.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Boughton, Charlotte KUNSPECIFIEDUNSPECIFIED
Munro, NeilUNSPECIFIEDUNSPECIFIED
Whyte, Martinm.b.whyte@surrey.ac.ukUNSPECIFIED
Date : 2017
Identification Number : 10.15277/bjd.2017.148
Copyright Disclaimer : ©2017 British Journal of Diabetes and ABCD (Diabetes Care) Limited. All rights reserved.
Uncontrolled Keywords : Type 2 diabetes (T2D); Beta-cell function; Remission
Related URLs :
Depositing User : Clive Harris
Date Deposited : 20 Dec 2017 15:00
Last Modified : 15 Jan 2018 09:16
URI: http://epubs.surrey.ac.uk/id/eprint/845491

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800