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The association between C-reactive protein, Interleukin-6 and depression among older adults in the community: a systematic review and meta-analysis

Smith, Kimberley, Au, B, Ollis, Lucie and Schmitz, N (2017) The association between C-reactive protein, Interleukin-6 and depression among older adults in the community: a systematic review and meta-analysis Experimental Gerontology, 102. pp. 109-132.

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Abstract

Previous research indicates there may be an association between inflammation and depression in older adults but results are inconsistent. Therefore, the aim of this review was to determine the cross-sectional and longitudinal associations of two inflammatory markers C-reactive protein (CRP) and Interleukin-6 (IL-6) with depression in older adults. We searched five databases for cross-sectional and longitudinal studies reporting an association between CRP or IL-6 with depression among adults sampled from the community aged 50 or older. We found 32 studies (23 cross-sectional, 7 longitudinal, and 2 assessing both cross-sectional and longitudinal associations) that met eligibility criteria. These studies were entered into a random-effects meta-analysis to determine the cross-sectional association and longitudinal direction of association between both IL-6 and CRP with depression. Results indicated a cross-sectional and longitudinal association between both CRP and IL-6 with depression in older adults, with inflammation leading to depression in longitudinal studies rather than depression to inflammation. However, there was notable heterogeneity between studies as results differed based on adjusting for confounders and on how inflammation and depression were measured. These sources of heterogeneity could explain differences in study results.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
NameEmailORCID
Smith, Kimberleykimberley.j.smith@surrey.ac.ukUNSPECIFIED
Au, BUNSPECIFIEDUNSPECIFIED
Ollis, Luciel.b.ollis@surrey.ac.ukUNSPECIFIED
Schmitz, NUNSPECIFIEDUNSPECIFIED
Date : 10 December 2017
Identification Number : 10.1016/j.exger.2017.12.005
Copyright Disclaimer : © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : C-reactive protein, Interleukin-6, depression, older adults, systematic review, meta-analysis
Depositing User : Melanie Hughes
Date Deposited : 19 Dec 2017 12:42
Last Modified : 26 Jan 2018 14:13
URI: http://epubs.surrey.ac.uk/id/eprint/845445

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