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Extracellular genomic biomarkers of osteoarthritis

Budd, Emma, Nalesso, Giovanna and Mobasheri, Ali (2017) Extracellular genomic biomarkers of osteoarthritis Expert Review of Molecular Diagnostics, 18 (1). pp. 55-74.

Extracellular Genomic Biomarkers of Osteoarthritis_Accepted Copy Dec 2017.pdf - Accepted version Manuscript

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Introduction: Osteoarthritis (OA), a chronic, debilitating and degenerative disease of the joints, is the most common form of arthritis. The seriousness of this prevalent and chronic disease is often overlooked. Disease modifying OA drug development is hindered by the lack of soluble biomarkers to detect OA early. The objective of OA biomarker research is to identify early OA prior to the appearance of radiographic signs and the development of pain.

Areas covered: This review has focused on extracellular genomic material that could serve as biomarkers of OA. Recent studies have examined the expression of extracellular genomic material such as miRNA, lncRNA, snoRNA, mRNA and cell-free DNA, which are aberrantly expressed in the body fluids of OA patients. Changes in genomic content of peripheral blood mononuclear cells in OA could also function as biomarkers of OA.

Expert commentary: There is an unmet need for soluble biomarkers for detecting and then monitoring OA disease progression. Extracellular genomic material research may also reveal more about the underlying pathophysiology of OA. Minimally-invasive liquid biopsies such as synovial fluid and blood sampling of genomic material may be more sensitive over radiography in the detection, diagnosis and monitoring of OA in the future.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
Date : 15 December 2017
DOI : 10.1080/14737159.2018.1415757
Copyright Disclaimer : This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Molecular Diagnostics on 15 December 2017, available online:
Uncontrolled Keywords : Osteoarthritis; Extracellular; Genomic biomarkers; Body fluids; Liquid biopsy; ncRNA; miRNA; cfDNA; mRNA; Extracellular nucleic acid carriers
Depositing User : Clive Harris
Date Deposited : 19 Dec 2017 09:41
Last Modified : 15 Dec 2018 02:08

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