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Cow's milk consumption increases iodine status in women of childbearing age in a randomized controlled trial

O'Kane, S. Maria, Pourshahidi, L. Kirsty, Mulhern, Maria S., Strain, J.J., Mackle, Emer M., Koca, Duygu, Schomburg, Lutz, Hill, Sarah, O’Reilly, Jennifer, Kmiotek, Diana , Deitrich, Christian, Bath, Sarah C. and Yeates, Alison J. (2017) Cow's milk consumption increases iodine status in women of childbearing age in a randomized controlled trial Journal of Nutrition.

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Abstract

Background: Recent evidence has highlighted the prevalence of mild-to-moderate iodine deficiency in women of childbearing age and pregnant women, with important public health ramifications owing to the role of iodine, required for thyroid hormone production, in neurodevelopment. Cow’s milk contributes the greatest amount to iodine intakes in several countries. Objective: The objective of this study was to investigate the effect of increased cow’s milk consumption on iodine status, thyroid hormone concentrations and selenium status.</p> Methods: A 12 week, randomized-controlled trial was conducted in 78 low-moderate milk consuming (<250ml/d) healthy women (18-45 years). The intervention group were asked to consume 3L of semi49 skimmed milk per week, while the control group continued their usual milk consumption (baseline median (IQR): 140 (40-240) mL/d). At baseline, week 6 and week 12 participants provided a spot51 urine sample [urinary iodine concentration (UIC); creatinine] and a fasting blood sample [thyroid hormone concentrations; serum total selenium; selenoprotein P]. This study was registered at ClinicalTrials.gov Study (Ref: NCT02767167). Results: At baseline, the median (IQR) UIC of all participants was 78.5 (39.1-126.1)μg/L. Changes in the median UIC from baseline to week 6 (35.4 vs. 0.6 μg/L; P=0.014) and week 12 (51.6 vs. -3.8 μg/L; P=0.045) were significantly greater in the intervention group compared with the control group. However, despite being higher within the intervention group at weeks 6 and 12, the change in the iodine:creatinine ratio from baseline was not significantly different between groups at either week 6 (P=0.637) or 12 (P=0.178). There were no significant differences in thyroid hormone concentrations or selenium status between groups at any time point. Conclusions: The present study has demonstrated that the consumption of additional cow’s milk can significantly increase UIC in women of childbearing age. These results suggest that cow’s milk is a potentially important dietary source of iodine in this population group.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
O'Kane, S. Maria
Pourshahidi, L. Kirsty
Mulhern, Maria S.
Strain, J.J.
Mackle, Emer M.
Koca, Duygu
Schomburg, Lutz
Hill, Sarah
O’Reilly, Jennifer
Kmiotek, Diana
Deitrich, Christian
Bath, Sarah C.s.bath@surrey.ac.uk
Yeates, Alison J.
Date : 2017
Copyright Disclaimer : © American Society for Nutrition 2017
Uncontrolled Keywords : Iodine; Women of childbearing age; Milk; Randomized-controlled trial; Iodine deficiency; Selenium
Depositing User : Clive Harris
Date Deposited : 12 Dec 2017 08:52
Last Modified : 14 Mar 2018 16:26
URI: http://epubs.surrey.ac.uk/id/eprint/845200

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