University of Surrey

Test tubes in the lab Research in the ATI Dance Research

The interfacial strength of bilayer pharmaceutical TABLETs

Zhang, Jianyi, Wu, Chuan-Yu, Storey, David and Byrne, Gerard (2017) The interfacial strength of bilayer pharmaceutical TABLETs Powder Technology.

[img] Text
The interfacial strength of bilayer pharmaceutical TABLETs.docx - Accepted version Manuscript

Download (1MB)


The oral drug delivery system using bilayer (or multilayer) tablets has become more commonly used in therapeutic strategies. However, one of the most common problems associated with bilayer tablets is the insufficient interfacial strength between layers, which leads to product failure during manufacturing. Therefore, it is important to better understand the interfacial strength of bilayer pharmaceutical tablets. For this purpose, in this study, the interfacial strength of bilayer tablets made of microcrystalline cellulose (MCC PH 102) at various manufacturing conditions was systematically examined. Three cases were considered: (1) the effect of interfacial curvature on the interfacial strength, for which the interfaces between two layers with different curvatures were produced using flat, convex and concave punches. (2) The effect of water content on the interfacial strength, for which the powder was conditioned at various relative humidity before being used to produce bilayer tablets. (3) The effect of the particle size of the powder used in first layer on the interfacial strength, for which the feed powder was sieved to obtain powders with specific particle sizes that were then used to produce the first layer of the bilayer tablets. For all cases considered, direct tensile tests were performed to measure the tablet interfacial strength. It is found that the interfacial curvature, the water content and the particle size in the first layer affected the interfacial strength significantly. It is also shown that the tablet interfacial strength was increased when larger particles were used in the first layer, or when curved punches (i.e. either convex or concave punches) were used to produce curved interfaces with increased interfacial areas. In addition, a higher interfacial strength can also be achieved by properly controlling water content in the powder.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
Storey, David
Byrne, Gerard
Date : 2017
Copyright Disclaimer : © 2017 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords : Bilayer tablet; Delamination; Interfacial strength; Punch curvature; Water content
Depositing User : Clive Harris
Date Deposited : 08 Dec 2017 13:30
Last Modified : 17 Oct 2019 09:29

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800