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Quantitative Analysis of Chiari-Like Malformation and Syringomyelia in the Griffon Bruxellois Dog

Knowler, SP, McFadyen, AK, Freeman, C, Kent, M, Platt, SR, Kibar, Z and Rusbridge, Clare (2014) Quantitative Analysis of Chiari-Like Malformation and Syringomyelia in the Griffon Bruxellois Dog PLoS ONE, 9 (2), e88120.

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Abstract

This study aimed to develop a system of quantitative analysis of canine Chiari-like malformation and syringomyelia on variable quality MRI. We made a series of measurements from magnetic resonance DICOM images from Griffon Bruxellois dogs with and without Chiari-like malformation and syringomyelia and identified several significant variables. We found that in the Griffon Bruxellois dog, Chiari-like malformation is characterized by an apparent shortening of the entire cranial base and possibly by increased proximity of the atlas to the occiput. As a compensatory change, there appears to be an increased height of the rostral cranial cavity with lengthening of the dorsal cranial vault and considerable reorganization of the brain parenchyma including ventral deviation of the olfactory bulbs and rostral invagination of the cerebellum under the occipital lobes.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Knowler, SP
McFadyen, AK
Freeman, C
Kent, M
Platt, SR
Kibar, Z
Rusbridge, Clarec.rusbridge@surrey.ac.uk
Date : 12 February 2014
Identification Number : 10.1371/journal.pone.0088120
Copyright Disclaimer : Copyright 2014 Knowler et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Depositing User : Melanie Hughes
Date Deposited : 05 Dec 2017 11:44
Last Modified : 05 Dec 2017 11:44
URI: http://epubs.surrey.ac.uk/id/eprint/845109

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