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Cytotoxic Ergostane Derivatives from the Edible Mushroom Termitomyces microcarpus (Lyophyllaceae)

Njue, Alice W., Omolo, Josiah O., Cheplogoi, Peter K., Langat, Moses K. and Mulholland, Dulcie Cytotoxic Ergostane Derivatives from the Edible Mushroom Termitomyces microcarpus (Lyophyllaceae) Biochemical Systematics and Ecology, 76. pp. 12-14.

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Abstract

Five ergostanes, dimethylincisterol (1), 5α,8α–epidioxy-(22E,24R)-ergosta-6,9(11),22-trien-3β-ol (2), 5α,8α–epidioxy-(22E,24R)-ergosta-6,22-dien-3β-ol (3), 5α,6α-epoxy-(22E,24R)-ergosta-8(14),22-diene-3β,7α-diol (4), (22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol (5) and betulinic acid (6) were isolated from the fresh fruiting bodies of the edible mushroom, Termitomyces microcarpus. The cytotoxicity of the compounds isolated was evaluated against the NCI 60 human cancer cell line panel. The degraded sterol dimethylincisterol (1) and 5α,8α–epidioxyergosta-6,22-dien-3β-ol (3) possessed cytotoxic activity at the 1 µM level.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Njue, Alice W.UNSPECIFIEDUNSPECIFIED
Omolo, Josiah O.UNSPECIFIEDUNSPECIFIED
Cheplogoi, Peter K.UNSPECIFIEDUNSPECIFIED
Langat, Moses K.UNSPECIFIEDUNSPECIFIED
Mulholland, DulcieD.Mulholland@surrey.ac.ukUNSPECIFIED
Identification Number : 10.1016/j.bse.2017.11.006
Copyright Disclaimer : © 2017 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords : Lyophyllaceae; Termitomyces microcarpus; Ergostanes; Antiproliferative activity; NCI60 panel
Additional Information : Supplementary data related to this article can be found at https://doi.org/10.1016/j.bse.2017.11.006.
Depositing User : Clive Harris
Date Deposited : 27 Nov 2017 15:23
Last Modified : 27 Nov 2017 15:23
URI: http://epubs.surrey.ac.uk/id/eprint/845046

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