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Framework and Tools A Framework for Modelling, Optimization and Control of Biomedical Systems

Pistikopoulos, EN, Naşcu, I and Velliou, Eirini (2017) Framework and Tools A Framework for Modelling, Optimization and Control of Biomedical Systems In: Modelling Optimization and Control of Biomedical Systems. Wiley, pp. 1-11.

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Drug delivery can be defined as the process of administering a pharmaceutical agent in the human body, including the consequent effects of this agent on the tissues and organs. Mathematical modelling of drug delivery can be divided into two different yet complementary approaches, the pharmacokinetic and pharmacodynamic approaches. Pharmacokinetics describes the effect of the drug in the body, by capturing absorption, distribution, diffusion and elimination of the drug. Pharmacodynamics describes the effects of a drug in the body, which are expressed mathematically by relations of drug dose-body responses. Usually, modelling of the drug delivery system requires a pharmacokinetic part, a pharmacodynamics part and a link between the two. Mathematical optimization and control of biomedical systems could lead to a better prediction of the optimal drug and/or therapy treatment for a specific disease.

Item Type: Book Section
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
Date : 29 December 2017
Identification Number : 10.1002/9781118965580.ch1
Copyright Disclaimer : Copyright 2018 John Wiley & Sons Ltd.
Uncontrolled Keywords : biomedical systems; drug delivery; mathematical modelling; pharmacodynamics; pharmacokinetic
Depositing User : Melanie Hughes
Date Deposited : 23 Nov 2017 14:07
Last Modified : 23 Nov 2017 14:46

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