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Investigation of Fullerenol-induced changes in poroelasticity of human hepatocellular carcinoma by AFM-based creep tests

Zhu, Xinyao, Cirovic, Srdjan, Shaheen, Aliah and Xu, Wei (2017) Investigation of Fullerenol-induced changes in poroelasticity of human hepatocellular carcinoma by AFM-based creep tests Biomechanics and Modeling in Mechanobiology.

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Abstract

In this study, atomic force microscopy (AFM) is used to investigate the alterations of the poropelastic properties of hepatocellular carcinoma (SMMC-7721) cells treated with fullerenol. The SMMC-7721 cells were subject to AFM-based creep tests and a corresponding poroelastic indentation model was used to determine the poroelastic parameters by curve fitting. Comparative analyses indicated that the both permeability and diffusion of fullerenol-treated cells increased significantly while their elastic modulus decreased by a small amount. From the change trend of the determined parameter, we verified the corresponding alternations of cytoskeleton (mainly filaments actin), which was reported by the previous study using confocal imaging method. Our investigation on SMMC-7721 cell reveals that the porpelastic properties could provide a better understanding how the cancer cells are affected by fullerenol or potentially other drugs which could find possible applications in drug efficacy test, cancer diagnosis and secure therapies.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Authors :
NameEmailORCID
Zhu, Xinyaoxz0003@surrey.ac.ukUNSPECIFIED
Cirovic, SrdjanS.Cirovic@surrey.ac.ukUNSPECIFIED
Shaheen, AliahA.Shaheen@surrey.ac.ukUNSPECIFIED
Xu, WeiW.Xu@surrey.ac.ukUNSPECIFIED
Date : 1 December 2017
Identification Number : 10.1007/s10237-017-0984-5
Copyright Disclaimer : © The Author(s) 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords : Atomic force microscope; Poroelastic; Permeability; Diffusion; Fullerenol; Creep
Depositing User : Clive Harris
Date Deposited : 20 Nov 2017 10:25
Last Modified : 06 Dec 2017 15:02
URI: http://epubs.surrey.ac.uk/id/eprint/844949

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