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The effectiveness and cost-effectiveness of plant sterol or stanol-enriched functional foods as a primary prevention strategy for people with cardiovascular disease risk in England: a modeling study

Yang, Wei, Gage, Heather, Jackson, Daniel and Raats, Monique (2017) The effectiveness and cost-effectiveness of plant sterol or stanol-enriched functional foods as a primary prevention strategy for people with cardiovascular disease risk in England: a modeling study The European Journal of Health Economics.

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Abstract

This study appraises the effectiveness and cost-effectiveness of consumption of plant sterol-enriched margarine-type spreads for the prevention of cardiovascular disease (CVD) in people with hypercholesterolemia in England, compared to a normal diet. A nested Markov model was employed using the perspective of the British National Health Service (NHS). Effectiveness outcomes were the 10-year CVD risk of individuals with mild (4–6 mmol/l) and high (above 6 mmol/l) cholesterol by gender and age groups (45–54, 55–64, 65–74, 75–85 years); CVD events avoided and QALY gains over 20 years. This study found that daily consumption of enriched spread reduces CVD risks more for men and older age groups. Assuming 50% compliance, 69 CVD events per 10,000 men and 40 CVD events per 10,000 women would be saved over 20 years. If the NHS pays the excess cost of enriched spreads, for the high-cholesterol group, the probability of enriched spreads being cost-effective is 100% for men aged over 64 years and women over 74, at £20,000/QALY threshold. Probabilities of cost-effectiveness are lower at younger ages, with mildly elevated cholesterol and over a 10-year time horizon. If consumers bear the full cost of enriched spreads, NHS savings arise from reduced CVD events.

Item Type: Article
Divisions : Faculty of Arts and Social Sciences > School of Economics
Authors :
NameEmailORCID
Yang, WeiUNSPECIFIEDUNSPECIFIED
Gage, HeatherH.Gage@surrey.ac.ukUNSPECIFIED
Jackson, DanielD.Jackson@surrey.ac.ukUNSPECIFIED
Raats, MoniqueM.Raats@surrey.ac.ukUNSPECIFIED
Date : 6 November 2017
Identification Number : 10.1007/s10198-017-0934-2
Copyright Disclaimer : This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords : Plant sterols; Cardiovascular disease risk; England; Cost-effectiveness analysis
Depositing User : Clive Harris
Date Deposited : 13 Nov 2017 15:48
Last Modified : 13 Nov 2017 15:48
URI: http://epubs.surrey.ac.uk/id/eprint/844888

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