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Antimicrobial activity of carbon monoxide-releasing 1 molecule [Mn(CO)3(tpa-k3N)]Br versus multidrug-2 resistant isolates of Avian Pathogenic Escherichia coli 3 and its synergy with colistin

Betts, Jonathan, Nagel, Christoph, Schatzschneider, Ulrich, Poole, Robert and La Ragione, Roberto (2017) Antimicrobial activity of carbon monoxide-releasing 1 molecule [Mn(CO)3(tpa-k3N)]Br versus multidrug-2 resistant isolates of Avian Pathogenic Escherichia coli 3 and its synergy with colistin PLoS ONE, 12 (10).

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Antimicrobial activity of carbon monoxide-releasing 1 molecule [Mn(CO)3(tpa-k3N)]Br versus multidrug-2 resistant isolates of Avian Pathogenic Escherichia coli 3 and its synergy with colistin.pdf - Accepted version Manuscript
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Abstract

The purpose of this study is to demonstrate the properties of novel nanocomposites, based on cycloaliphatic epoxy resin additionally reinforced with silicon-containing nanostructures (mono- or octa-functional POSS or nanosilica). The changes in properties are discussed for the varied combinations of cycloaliphatic epoxy with a curing agent (cycloaliphatic amine or anhydride) and the nanomodifier. The in uence of modification on thermal stability, curing behaviour, morphology, surface chemistry, and topography were studied with TGA, DSC, ATR-FTIR, XPS and LCM. The results show that when POSS and/or nanosilica are incorporated to the cycloaliphatic matrix they in uence curing behaviour and glass transition temperatures (Tg), where mono-POSS increases Tg and octa-POSS decreases it with respect to nanosilica. Mono-POSS produces silicon-rich surfaces but tends to agglomerate and increase surface roughness. Octa-POSS and nanosilica penetrate the polymer matrix more deeply and disperse more easily. From the selected modifiers, octa-POSS shows the highest thermal stability.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Betts, Jonathanjono.betts@surrey.ac.uk
Nagel, Christoph
Schatzschneider, Ulrich
Poole, Robert
La Ragione, RobertoR.Laragione@surrey.ac.uk
Date : 17 October 2017
Funders : Biotechnology and Biological Sciences Research Council (BBSRC)
Identification Number : 10.1371/journal.pone.0186359
Copyright Disclaimer : © 2017 Betts et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords : Multidrug-resistant; Avian pathogenic Escherichia coli; Synergy; In vivo; Manganese complex
Depositing User : Clive Harris
Date Deposited : 08 Nov 2017 15:27
Last Modified : 14 Mar 2018 13:22
URI: http://epubs.surrey.ac.uk/id/eprint/844869

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