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Prevalence of cancer chemotherapy-related problems, their relation to health-related quality of life and associated supportive care: a cross-sectional survey

Wagland, Richard, Richardson, A, Ewings, Sean, Armes, Jo, Lennan, Elaine, Hankins, Matthew and Griffiths, Peter (2016) Prevalence of cancer chemotherapy-related problems, their relation to health-related quality of life and associated supportive care: a cross-sectional survey Supportive Care in Cancer, 24 (12). pp. 4901-4911.

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Abstract

Purpose The purpose of this study was to identify the treatment-associated problems that most impact on patients undergoing cancer chemotherapy, how problems relate to experiences of supportive care and variations in experience between cancer treatment centres.

Methods A survey administered to patients at six cancer centres in England explored variations of prevalence of 17 cancer chemotherapy-associated problems and associated supportive care. Problem items were identified as the most frequently experienced and severe when experienced in a scoping and consensus exercise. A health-related quality of life (HRQoL) measure, the EQ5D, was included to measure impact of problems.

Results A total of 363 completed questionnaires were returned (response rate 43 %, median 61 %). The most prevalent problem was ‘tiredness/fatigued’ (90 %), followed by ‘changes in taste & smell’ (69 %) and ‘difficulty managing everyday tasks’ (61 %). Significant variations in problem prevalence existed between centres, and some common problems were rarely reported in the literature. Regression analysis found that almost all problems were significantly associated with HRQoL, with social/emotional problems having as much impact on HRQoL as physical/psychological side effects of treatment. Greatest effect size was for difficulty managing everyday tasks. Respondents reported significant variations in supportive care between centres, with more supportive care received for physical/psychological problems than for social/emotional problems. Findings indicated that patients who received increased supportive care experienced less severe problems.

Conclusion The most common and distressing chemotherapy-associated problems were identified. These problems are mitigated by quality supportive care. Routine measurement and monitoring of problem items and supportive care are warranted to facilitate benchmarking and service improvements both within and between cancer centres.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Health Sciences
Authors :
NameEmailORCID
Wagland, RichardUNSPECIFIEDUNSPECIFIED
Richardson, AUNSPECIFIEDUNSPECIFIED
Ewings, SeanUNSPECIFIEDUNSPECIFIED
Armes, Jojo.armes@surrey.ac.ukUNSPECIFIED
Lennan, ElaineUNSPECIFIEDUNSPECIFIED
Hankins, MatthewUNSPECIFIEDUNSPECIFIED
Griffiths, PeterUNSPECIFIEDUNSPECIFIED
Date : 27 July 2016
Identification Number : 10.1007/s00520-016-3346-4
Copyright Disclaimer : © Springer-Verlag Berlin Heidelberg 2016
Uncontrolled Keywords : Cancer; Supportive care; Treatment-associated problems; Health-related quality of life (HRQoL)
Depositing User : Clive Harris
Date Deposited : 30 Oct 2017 13:24
Last Modified : 30 Oct 2017 13:24
URI: http://epubs.surrey.ac.uk/id/eprint/844683

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