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Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis

Hingley-Wilson, Suzie, Sambandamurthy, VK and Jacobs, WR Jr (2003) Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis Nature Immunology, 4 (10). pp. 949-955.

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Abstract

Studying defined mutants of Mycobacterium tuberculosis in the mouse model of infection has led to the discovery of attenuated mutants that fall into several phenotypic classes. These mutants are categorized by their growth characteristics compared with those of wild-type M. tuberculosis, and include severe growth in vivo mutants, growth in vivo mutants, persistence mutants, pathology mutants and dissemination mutants. Here, examples of each of these mutant phenotypes are described and classified accordingly. Defining the importance of mycobacterial gene products responsible for in vivo growth, persistence and the induction of immunopathology will lead to a greater understanding of the host-pathogen interaction and potentially to new antimycobacterial treatment options.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Hingley-Wilson, Suzies.hingley-wilson@surrey.ac.ukUNSPECIFIED
Sambandamurthy, VKUNSPECIFIEDUNSPECIFIED
Jacobs, WR JrUNSPECIFIEDUNSPECIFIED
Date : 26 September 2003
Identification Number : 10.1038/ni981
Copyright Disclaimer : Copyright © 2003, Rights Managed by Nature Publishing Group
Depositing User : Jane Hindle
Date Deposited : 26 Oct 2017 12:17
Last Modified : 26 Oct 2017 12:17
URI: http://epubs.surrey.ac.uk/id/eprint/844662

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