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The effect of thiazolidinediones on lipoprotein metabolism: A double blind randomised placebo controlled trial using stable isotopes to investigate the effect of pioglitazone, rosiglitazone and placebo on lipoprotein(apolipoprotein B100, VLDL, IDL and LDL) metabolism.

Brackenridge, Anna. (2005) The effect of thiazolidinediones on lipoprotein metabolism: A double blind randomised placebo controlled trial using stable isotopes to investigate the effect of pioglitazone, rosiglitazone and placebo on lipoprotein(apolipoprotein B100, VLDL, IDL and LDL) metabolism. Doctoral thesis, University of Surrey (United Kingdom)..

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Abstract

+/- 0.82) with well controlled diabetes (mean HbAlc7.02% +/- 0.15), and lipids (mean total cholesterol 4.91mmol/l +/- 0.17, mean HDL cholesterol 1.21mmol/l +/- 0.06, median triglyceride 1.61 mmol/1 [1.22, 1.97]) at baseline. Following treatment there was a significant reduction in HbAlc in the rosiglitazone (-0.48%, p < 0.05) and the pioglitazone group (-0.71%, p < 0.05), a significant reduction in free fatty acids in both active treatment groups but no change in any other lipid variable. There was a significant reduction in VLDL apo B absolute secretion rate in the rosiglitazone group (-2.19nig/kg/day, p = 0.017) but no change in catabolic rate in any group and no change in IDL or LDL metabolism. These results were not as expected and reasons for this are discussed.

Item Type: Thesis (Doctoral)
Divisions : Theses
Authors :
NameEmailORCID
Brackenridge, Anna.UNSPECIFIEDUNSPECIFIED
Date : 2005
Contributors :
ContributionNameEmailORCID
http://www.loc.gov/loc.terms/relators/THSUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Depositing User : EPrints Services
Date Deposited : 09 Nov 2017 12:14
Last Modified : 09 Nov 2017 14:42
URI: http://epubs.surrey.ac.uk/id/eprint/843498

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