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Application of polymer supported catalysts to the tritiation of organic compounds.

Brewer, Jason Robert. (1991) Application of polymer supported catalysts to the tritiation of organic compounds. Doctoral thesis, University of Surrey (United Kingdom)..

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Abstract

As more active pharmacological agents are discovered, the study of their absorption, distribution and metabolism is made more difficult by the resulting lower dosage levels. The role of radioactive isotopes is central to this work, consequently great effort has been made towards the discovery of routes to molecules labelled with radioactive isotopes. The work discussed in this thesis represents the first application of polymer supported catalysis in the tritiation of organic molecules. Where appropriate, 3H NMR spectroscopy was used to delineate labelling patterns, which in turn allow mechanistic inferences to be made. The scope of the method has been extensively examined, and advantages of the polymer supported heterogeneous system, such as the ease of catalyst separation and the possibility of obtaining unique selectivity, are highlighted.

Item Type: Thesis (Doctoral)
Divisions : Theses
Authors :
NameEmailORCID
Brewer, Jason Robert.UNSPECIFIEDUNSPECIFIED
Date : 1991
Contributors :
ContributionNameEmailORCID
http://www.loc.gov/loc.terms/relators/THSUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Depositing User : EPrints Services
Date Deposited : 09 Nov 2017 12:12
Last Modified : 09 Nov 2017 14:40
URI: http://epubs.surrey.ac.uk/id/eprint/842948

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