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Escherichia coli O157:H7 colonisation in small domestic ruminants

La Ragione, Roberto, Best, A, Woodward, MJ and Wales, Andrew (2009) Escherichia coli O157:H7 colonisation in small domestic ruminants FEMS Microbiology Reviews, 33 (2). pp. 394-410.

05 FEMS Microbiol Rev (2009) 33, 394-410.pdf - Accepted version Manuscript

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Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 was first implicated in human disease in the early 1980s, with ruminants cited as the primary reservoirs. Preliminary studies indicated cattle to be the sole source of E. coli O157:H7 outbreaks in humans, however further epidemiological studies soon demonstrated that E. coli O157:H7 was widespread in other food sources and that a number of transmission routes existed. More recently, small domestic ruminants (sheep and goats) have emerged as important sources of E. coli O157:H7 human infection, particularly with the widespread popularity of petting farms and the increased use of sheep and goat food products, including unpasteurised cheeses. Although the colonisation and persistence characteristics of E. coli O157:H7 in the bovine host have been studied intensively, this is not the case for small ruminants. Despite many similarities with the bovine host, the pathobiology of E. coli O157:H7 in small domestic ruminants does appear to differ significantly from that described in cattle. This review aims to critically review the current knowledge regarding colonisation and persistence of E. coli O157:H7 in small domestic ruminants, including comparisons with the bovine host where appropriate.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
La Ragione,
Best, A
Woodward, MJ
Date : March 2009
DOI : 10.1111/j.1574-6976.2008.00138.x
Copyright Disclaimer : Copyright 2009 Oxford University Press
Uncontrolled Keywords : Sheep, goats, E. coli O157:H7, colonisation, persistence
Depositing User : Melanie Hughes
Date Deposited : 25 Oct 2017 10:35
Last Modified : 16 Jan 2019 18:58

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