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Modulation of adult hippocampal neurogenesis by sleep: Impact on mental health

Navarro-Sanchis, C, Brock, O, Winsky-Sommerer, Raphaelle-Valia and Thuret, S (2017) Modulation of adult hippocampal neurogenesis by sleep: Impact on mental health Frontiers in Neural Circuits, 11, 74.

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Abstract

The process of neurogenesis has been demonstrated to occur throughout life in the subgranular zone (SGZ) of the hippocampal dentate gyrus of several mammals, including humans. The basal rate of adult hippocampal neurogenesis can be altered by lifestyle and environmental factors. In this perspective review, the evidence for sleep as a modulator of adult hippocampal neurogenesis is first summarized. Following this, the impacts of sleep and sleep disturbances on hippocampal-dependent functions, including learning and memory, and depression are critically evaluated. Finally, we postulate that the effects of sleep on hippocampal-dependent functions may possibly be mediated by a change in adult hippocampal neurogenesis. This could provide a route to new treatments for cognitive impairments and psychiatric disorders.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Navarro-Sanchis, C
Brock, O
Winsky-Sommerer, Raphaelle-ValiaR.Winsky-Sommerer@surrey.ac.uk
Thuret, S
Date : 12 October 2017
Funders : BBSRC, BSRC
Identification Number : 10.3389/fncir.2017.00074
Copyright Disclaimer : © 2017 Navarro-Sanchis, Brock, Winsky-Sommerer and Thuret. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords : Keywords: neurogenic niche, plasticity, cognition, sleep disruption, memory, psychiatric disorders, mood, depression
Depositing User : Melanie Hughes
Date Deposited : 20 Oct 2017 15:19
Last Modified : 09 May 2018 11:05
URI: http://epubs.surrey.ac.uk/id/eprint/842622

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