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Efficacy of a Live Attenuated Escherichia coli O78∶K80 Vaccine in Chickens and Turkeys

La Ragione, Roberto, Woodward, MJ, Kumar, M, Rodenberg, J, Fan, H, Wales, Andrew and Karaca, K (2013) Efficacy of a Live Attenuated Escherichia coli O78∶K80 Vaccine in Chickens and Turkeys Avian Diseases, 57 (2). pp. 273-279.

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A candidate live vaccine for avian pathogenic Escherichia coli (APEC) was constructed from a virulent field APEC O78 strain by mutation of the aroA gene. The mutant was highly similar to the parent wild-type strain in respect of colony morphology, motility, growth in suspension, hemagglutination, Congo Red binding, HEp-2 cell adhesion, and the elaboration of surface antigens type 1 fimbriae and flagella, although production of curli fimbriae was reduced marginally. The mutant proved avirulent when inoculated into 1-day-old chicks by spray application and when presented again in the drinking water at 7 days of age. Chickens and turkeys vaccinated with an O78 aroA mutant were protected against a challenge at 6 wk of age by virulent APEC strains.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
La Ragione,
Woodward, MJ
Kumar, M
Rodenberg, J
Fan, H
Karaca, K
Date : 1 March 2013
DOI : 10.1637/10326-081512-Reg.1
Copyright Disclaimer : Copyright 2013 American Association of Avian Pathologists
Uncontrolled Keywords : Escherichia coli, avian pathogenic Escherichia coli, chicken, turkey, PCR, avian, phenotypic, vaccine, genotypic
Depositing User : Users 8 not found.
Date Deposited : 20 Oct 2017 08:44
Last Modified : 06 Jul 2019 05:24

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