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Efficacy of a Live Attenuated Escherichia coli O78∶K80 Vaccine in Chickens and Turkeys

La Ragione, Roberto, Woodward, MJ, Kumar, M, Rodenberg, J, Fan, H, Wales, Andrew and Karaca, K (2013) Efficacy of a Live Attenuated Escherichia coli O78∶K80 Vaccine in Chickens and Turkeys Avian Diseases, 57 (2). pp. 273-279.

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Abstract

A candidate live vaccine for avian pathogenic Escherichia coli (APEC) was constructed from a virulent field APEC O78 strain by mutation of the aroA gene. The mutant was highly similar to the parent wild-type strain in respect of colony morphology, motility, growth in suspension, hemagglutination, Congo Red binding, HEp-2 cell adhesion, and the elaboration of surface antigens type 1 fimbriae and flagella, although production of curli fimbriae was reduced marginally. The mutant proved avirulent when inoculated into 1-day-old chicks by spray application and when presented again in the drinking water at 7 days of age. Chickens and turkeys vaccinated with an O78 aroA mutant were protected against a challenge at 6 wk of age by virulent APEC strains.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
La Ragione, RobertoR.Laragione@surrey.ac.ukUNSPECIFIED
Woodward, MJUNSPECIFIEDUNSPECIFIED
Kumar, MUNSPECIFIEDUNSPECIFIED
Rodenberg, JUNSPECIFIEDUNSPECIFIED
Fan, HUNSPECIFIEDUNSPECIFIED
Wales, Andrewaw0051@surrey.ac.uk0000-0002-8657-3007
Karaca, KUNSPECIFIEDUNSPECIFIED
Date : 1 March 2013
Identification Number : 10.1637/10326-081512-Reg.1
Copyright Disclaimer : Copyright 2013 American Association of Avian Pathologists
Uncontrolled Keywords : Escherichia coli, avian pathogenic Escherichia coli, chicken, turkey, PCR, avian, phenotypic, vaccine, genotypic
Depositing User : Melanie Hughes
Date Deposited : 20 Oct 2017 08:44
Last Modified : 24 Oct 2017 12:01
URI: http://epubs.surrey.ac.uk/id/eprint/842615

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