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Progranulin as a biomarker and potential therapeutic agent

Abella, V, Pino, J, Scotece, M, Conde, J, Lago, F, Gonzalez-Gay, MA, Mera, A, Gómez, R, Mobasheri, Ali and Gualillo, O (2017) Progranulin as a biomarker and potential therapeutic agent Drug Discovery Today, 22 (10). pp. 1557-1564.

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Abstract

Progranulin is a cysteine-rich secreted protein with diverse pleiotropic actions and participates in several processes, such as inflammation or tumorigenesis. Progranulin was first identified as a growth factor and, recently, it was characterised as an adipokine implicated in obesity, insulin resistance and rheumatic disease. At a central level, progranulin acts as a neurotropic and neuroprotective factor and protects from neural degeneration. In this review, we summarise the most recent research advances concerning the potential role of progranulin as a therapeutic target and biomarker in cancer, neurodegenerative and inflammatory diseases.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Abella, VUNSPECIFIEDUNSPECIFIED
Pino, JUNSPECIFIEDUNSPECIFIED
Scotece, MUNSPECIFIEDUNSPECIFIED
Conde, JUNSPECIFIEDUNSPECIFIED
Lago, FUNSPECIFIEDUNSPECIFIED
Gonzalez-Gay, MAUNSPECIFIEDUNSPECIFIED
Mera, AUNSPECIFIEDUNSPECIFIED
Gómez, RUNSPECIFIEDUNSPECIFIED
Mobasheri, Alia.mobasheri@surrey.ac.ukUNSPECIFIED
Gualillo, OUNSPECIFIEDUNSPECIFIED
Date : 23 June 2017
Identification Number : 10.1016/j.drudis.2017.06.006
Copyright Disclaimer : © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User : Melanie Hughes
Date Deposited : 18 Oct 2017 10:35
Last Modified : 24 Oct 2017 07:51
URI: http://epubs.surrey.ac.uk/id/eprint/842568

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