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Homocysteine concentrations in the cognitive progression of Alzheimer's disease

Farina, Nicolas, Jernerén, Fredrik, Turner, Cheryl, Hart, Kathryn and Tabet, Naji (2017) Homocysteine concentrations in the cognitive progression of Alzheimer's disease Experimental Gerontology, 99. pp. 146-150.

Homocysteine concentrations in the cognitive progression of Alzheimer’s disease.pdf - Accepted version Manuscript

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Objectives: Hyperhomocysteinemia in Alzheimer’s disease (AD) is widely reported and appears to worsen as the disease progresses. While active dietary intervention with vitamins B12 and folate decreases homocysteine blood levels, with promising clinical outcomes in Mild Cognitive Impairment (MCI), this so far has not been replicated in established AD populations. The aim of the study is to explore the relationship between hyperhomocystenemia and relevant vitamins as the disease progresses. Methods: In this longitudinal cohort study, 38 participants with mild to moderate AD were followed for an average period of 13 months. Plasma folate, vitamin B12 and homocysteine concentrations were measured at baseline and at follow-up. Dietary intake of B vitamins was also measured. Spearman’s correlations were conducted by homocysteine and B vitamin status. Results: As expected, cognitive status significantly declined over the follow-up period and this was paralleled by a significant increase in homocysteine concentrations (p=0.006). However, during this follow-up period there was no significant decline in neither dietary intake, nor the corresponding blood concentrations of vitamin B12/folate, with both remaining within normal values. Changes in blood concentrations of B vitamins were not associated with changes in homocysteine levels (p>0.05). Conclusion: In this study, the increase in homocysteine observed in AD patients as the disease progresses cannot be solely explained by dietary and blood levels of folate and vitamin B12. Other dietary and non-dietary factors may contribute to hyperhomocysteinemia and its toxic effect in AD, which needs to be explored to optimise timely intervention strategies.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Farina, Nicolas
Jernerén, Fredrik
Turner, Cheryl
Tabet, Naji
Date : 10 October 2017
Funders : Economic and Social Research Council (ESRC), Medical Research Council (MRC)
DOI : 10.1016/j.exger.2017.10.008
Copyright Disclaimer : © 2017 Elsevier Inc. All rights reserved.
Uncontrolled Keywords : Homocysteine; B vitamins; Alzheimer’s disease; Cognition
Depositing User : Clive Harris
Date Deposited : 12 Oct 2017 07:46
Last Modified : 11 Dec 2018 11:23

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