University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Improving the Prediction of Phosphate Dynamics in Biotechnological Processes: A Case Study Based on Antibiotic Production Using Streptomyces coelicolor

Bürger, P, Flores-Alsina, X, Arellano-Garcia, Harvey and Gernaey, KV (2017) Improving the Prediction of Phosphate Dynamics in Biotechnological Processes: A Case Study Based on Antibiotic Production Using Streptomyces coelicolor In: 27th European Symposium on Computer Aided Process Engineering – ESCAPE 27, Oct 1 - 5 2017, Barcelona, Spain.

Full text not available from this repository.

Abstract

The objective of this study is to demonstrate that the accurate mathematical description of phosphate dynamics requires a considerable, but unavoidable, degree of complexity when modelling biotechnological systems. As an example, a model predicting antibiotic production using Streptomyces coelicolor is chosen which had difficulties explaining the phosphate dynamics. The model is enhanced by the implementation of an advanced speciation model and a multiple mineral precipitation framework. Furthermore, a model describing intracellular polyphosphate accumulation and consumption is developed and implemented. Based on the conducted work the improved process model is capable of predicting the phosphate dynamics (RMSE≤ 52h: -90 %, RAD≤ 52h: -96 %) very accurately in comparison to the original implementation, where biomass growth was the only phosphate sink. The description of most other variables was improved by a knowledge-based re-estimation of selected parameters as well. This work contributes to the existing process knowledge of biotechnological systems in general and especially to the antibiotic production with S. coelicolor, which emphasizes the necessity of combining physico-chemical and biological processes to accurately describe phosphate dynamics.

Item Type: Conference or Workshop Item (Conference Paper)
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Bürger, PUNSPECIFIEDUNSPECIFIED
Flores-Alsina, XUNSPECIFIEDUNSPECIFIED
Arellano-Garcia, Harveyh.arellano-garcia@surrey.ac.ukUNSPECIFIED
Gernaey, KVUNSPECIFIEDUNSPECIFIED
Date : 9 November 2017
Identification Number : 10.1016/B978-0-444-63965-3.50480-3
Copyright Disclaimer : © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Streptomyces coelicolor; process modelling; speciation; precipitation; polyphosphate
Related URLs :
Depositing User : Melanie Hughes
Date Deposited : 22 Sep 2017 16:35
Last Modified : 17 Jan 2018 14:31
URI: http://epubs.surrey.ac.uk/id/eprint/842392

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800