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Using Benford’s Law to Detect Anomalies in Electroencephalogram: An Application to Detecting Alzheimer’s Disease

Tirunagari, Santosh, Abasolo, Daniel Emilio, Iorliam, A, Ho, Anthony and Poh, Norman (2017) Using Benford’s Law to Detect Anomalies in Electroencephalogram: An Application to Detecting Alzheimer’s Disease In: IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology (IEEE CIBCB 2017), 23 - 25 August 2017, Manchester, UK.

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease caused by the progressive death of brain cells over time. It represents the most frequent cause of dementia in the western world, and affects an individual’s cognitive ability and psychological capacity. While clinical diagnoses of AD are made primarily on the basis of clinical evaluation and mental health tests, diagnostic certainty is only possible through necropsy. One non-invasive approach to investigating AD is to use electroencephalograms (EEGs), which reflect brain electrical activity and so can be used to detect electrical abnormalities in brain signals with non-invasive cranial surface electrodes. Generally EEGs in AD patients show a shift to lower frequencies in spectral analysis and display less complexity and contain more regular patterns compared to those of control subjects. Here we present a method for differentiating AD patients from healthy ones based on their EEG signals using Benford’s law and support vector machines (SVMs) with a radial basis function (RBF) kernel. EEG signals from eleven AD and eleven age-matched controls were divided into artefact-free 5-sec epochs and used to train an SVM. 10 fold cross validation was performed at both the epochand subject-level to evaluate the importance of each electrode in discriminating between AD and healthy subjects. Substantive variability was seen across the different electrodes, with electrodes O1, O2 and C4 particularly being important. Performance across the electrodes was reduced when subject-level cross validation was performed, but relative performance across the electrodes was consistent with that found using epoch-level cross validation.

Item Type: Conference or Workshop Item (Conference Paper)
Divisions : Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Authors :
NameEmailORCID
Tirunagari, Santoshsantosh.tirunagari@surrey.ac.ukUNSPECIFIED
Abasolo, Daniel EmilioD.Abasolo@surrey.ac.ukUNSPECIFIED
Iorliam, AUNSPECIFIEDUNSPECIFIED
Ho, AnthonyA.Ho@surrey.ac.ukUNSPECIFIED
Poh, NormanN.Poh@surrey.ac.ukUNSPECIFIED
Date : 21 December 2017
Copyright Disclaimer : © 2017 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Related URLs :
Depositing User : Melanie Hughes
Date Deposited : 21 Sep 2017 09:18
Last Modified : 21 Sep 2017 09:18
URI: http://epubs.surrey.ac.uk/id/eprint/842363

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