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Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering

Matta-Domjan, Brigitta, King, Alice, Totti, Stella, Matta, Csaba, Dover, George, Martinez, Patricia, Zakhidov, Anvar, La Ragione, Roberto, Macedo, Hugo, Jurewicz, Izabela , Dalton, Alan and Velliou, Eirini (2017) Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering Journal of Biomedical Materials Research Part B-Applied Biomaterials.

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Abstract

Novel synthetic biomaterials able to support, direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds -which are easily tuneable to form sheets/fibres- support growth, proliferation and spatial organisation of pancreatic cancer cells, indicating their great potential in cancer tissue engineering.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Matta-Domjan, BrigittaUNSPECIFIEDUNSPECIFIED
King, AliceUNSPECIFIEDUNSPECIFIED
Totti, StellaUNSPECIFIEDUNSPECIFIED
Matta, CsabaUNSPECIFIEDUNSPECIFIED
Dover, GeorgeUNSPECIFIEDUNSPECIFIED
Martinez, PatriciaUNSPECIFIEDUNSPECIFIED
Zakhidov, AnvarUNSPECIFIEDUNSPECIFIED
La Ragione, RobertoUNSPECIFIEDUNSPECIFIED
Macedo, HugoUNSPECIFIEDUNSPECIFIED
Jurewicz, IzabelaIzabela.Jurewicz@surrey.ac.ukUNSPECIFIED
Dalton, AlanUNSPECIFIEDUNSPECIFIED
Velliou, Eirinie.velliou@surrey.ac.ukUNSPECIFIED
Date : 2017
Funders : EPSRC -IAA, EPSRC
Grant Title : EPSRC -IAA, EPSRC
Uncontrolled Keywords : biocompatible pristine carbon nanotube substrate; pancreatic adenocarcinoma; pancreatic cancer tissue engineering; extracellular matrix
Depositing User : Jane Hindle
Date Deposited : 19 Sep 2017 10:41
Last Modified : 19 Sep 2017 10:41
URI: http://epubs.surrey.ac.uk/id/eprint/842313

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