Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering

Matta-Domjan, Brigitta, King, Alice, Totti, Stella, Matta, Csaba, Dover, George, Martinez, Patricia, Zakhidov, Anvar, La Ragione, Roberto, Macedo, Hugo, Jurewicz, Izabela et al, Dalton, Alan and Velliou, Eirini (2017) Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering Journal of Biomedical Materials Research Part B-Applied Biomaterials, 106 (5). pp. 1637-1644.

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Abstract

Novel synthetic biomaterials able to support, direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds -which are easily tuneable to form sheets/fibres- support growth, proliferation and spatial organisation of pancreatic cancer cells, indicating their great potential in cancer tissue engineering.

Item Type:	Article
Divisions :	Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :	Name Email ORCID Matta-Domjan, Brigitta King, Alice Totti, Stella styliani.totti@surrey.ac.uk Matta, Csaba Dover, George Martinez, Patricia Zakhidov, Anvar La Ragione, Roberto Macedo, Hugo Jurewicz, Izabela Izabela.Jurewicz@surrey.ac.uk Dalton, Alan Velliou, Eirini e.velliou@surrey.ac.uk
Date :	4 October 2017
Funders :	EPSRC -IAA, EPSRC
DOI :	10.1002/jbm.b.34012
Copyright Disclaimer :	This is the peer reviewed version of the following article: Matta-Domjan, B, King, A, Totti, S, Matta, C, Dover, G, Martinez, P, Zakhidov, A, La Ragione, R, Macedo, H, Jurewicz, I, Dalton, A, Velliou, EG 2017. Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering. J Biomed Mater Res Part B 2017:00B:000–000, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.34012/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords :	biocompatible pristine carbon nanotube substrate; pancreatic adenocarcinoma; pancreatic cancer tissue engineering; extracellular matrix
Depositing User :	Jane Hindle
Date Deposited :	19 Sep 2017 10:41
Last Modified :	13 Sep 2019 09:46
URI:	http://epubs.surrey.ac.uk/id/eprint/842313

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