University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering

Matta-Domjan, Brigitta, King, Alice, Totti, Stella, Matta, Csaba, Dover, George, Martinez, Patricia, Zakhidov, Anvar, La Ragione, Roberto, Macedo, Hugo, Jurewicz, Izabela , Dalton, Alan and Velliou, Eirini (2017) Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering Journal of Biomedical Materials Research Part B-Applied Biomaterials.

[img] Text
Matta et al_accepted_manuscript_for_library.docx - Accepted version Manuscript
Restricted to Repository staff only until 4 October 2018.

Download (80kB)

Abstract

Novel synthetic biomaterials able to support, direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds -which are easily tuneable to form sheets/fibres- support growth, proliferation and spatial organisation of pancreatic cancer cells, indicating their great potential in cancer tissue engineering.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Matta-Domjan, Brigitta
King, Alice
Totti, Stella
Matta, Csaba
Dover, George
Martinez, Patricia
Zakhidov, Anvar
La Ragione, Roberto
Macedo, Hugo
Jurewicz, IzabelaIzabela.Jurewicz@surrey.ac.uk
Dalton, Alan
Velliou, Eirinie.velliou@surrey.ac.uk
Date : 4 October 2017
Funders : EPSRC -IAA, EPSRC
Identification Number : 10.1002/jbm.b.34012
Grant Title : EPSRC -IAA, EPSRC
Copyright Disclaimer : This is the peer reviewed version of the following article: Matta-Domjan, B, King, A, Totti, S, Matta, C, Dover, G, Martinez, P, Zakhidov, A, La Ragione, R, Macedo, H, Jurewicz, I, Dalton, A, Velliou, EG 2017. Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering. J Biomed Mater Res Part B 2017:00B:000–000, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.34012/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords : biocompatible pristine carbon nanotube substrate; pancreatic adenocarcinoma; pancreatic cancer tissue engineering; extracellular matrix
Depositing User : Jane Hindle
Date Deposited : 19 Sep 2017 10:41
Last Modified : 17 Jan 2018 10:15
URI: http://epubs.surrey.ac.uk/id/eprint/842313

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800