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Circadian phase resetting by a single short-duration light exposure

Rahman, SA, St. Hilaire, MA, Chang, A-M, Santhi, Nayantara, Duffy, JF, Kronauer, RE, Czeisler, CA, Lockley, SW and Klerman, EB (2017) Circadian phase resetting by a single short-duration light exposure JCI Insight, 2 (7), e89494.

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Abstract

BACKGROUND. In humans, a single light exposure of 12 minutes and multiple-millisecond light exposures can shift the phase of the circadian pacemaker. We investigated the response of the human circadian pacemaker to a single 15-second or 2-minute light pulse administered during the biological night. METHODS. Twenty-six healthy individuals participated in a 9-day inpatient protocol that included assessment of dim light melatonin onset time (DLMO time) before and after exposure to a single 15-second (n = 8) or 2-minute (n = 12) pulse of bright light (9,500 lux; 4,100 K fluorescent) or control background dim light (<3 lux; n = 6). Phase shifts were calculated as the difference in clock time between the two phase estimates. RESULTS. Both 15-second and 2-minute exposures induced phase delay shifts [median (± SD)] of –34.8 ± 47.2 minutes and –45.4 ± 28.4 minutes, respectively, that were significantly (P = 0.04) greater than the control condition (advance shift: +22.3 ± 51.3 minutes) but were not significantly different from each other. Comparisons with historic data collected under the same conditions confirmed a nonlinear relationship between exposure duration and the magnitude of phase shift. CONCLUSIONS. Our results underscore the exquisite sensitivity of the human pacemaker to even short-duration single exposures to light. These findings may have real-world implications for circadian disruption induced by exposure to brief light stimuli at night.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Rahman, SAUNSPECIFIEDUNSPECIFIED
St. Hilaire, MAUNSPECIFIEDUNSPECIFIED
Chang, A-MUNSPECIFIEDUNSPECIFIED
Santhi, NayantaraN.Santhi@surrey.ac.ukUNSPECIFIED
Duffy, JFUNSPECIFIEDUNSPECIFIED
Kronauer, REUNSPECIFIEDUNSPECIFIED
Czeisler, CAUNSPECIFIEDUNSPECIFIED
Lockley, SWUNSPECIFIEDUNSPECIFIED
Klerman, EBUNSPECIFIEDUNSPECIFIED
Date : 6 April 2017
Identification Number : 10.1172/jci.insight.89494
Copyright Disclaimer : Copyright 2017 American Society for Clinical Investigation
Depositing User : Melanie Hughes
Date Deposited : 15 Sep 2017 16:07
Last Modified : 15 Sep 2017 16:07
URI: http://epubs.surrey.ac.uk/id/eprint/842298

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