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Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium

Lophatananon, Artitaya, Stewart-Brown, Sarah, Kote-Jarai, Zsofia, Olama, Ali Amin Al, Garcia, Sara Benlloch, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Giles, Graham G, Fitzgerald, Liesel M , Southey, Melissa C, Pharoah, Paul, Pashayan, Nora, Gronberg, Henrik, Wiklund, Fredrik, Aly, Markus, Stanford, Janet L, Brenner, Hermann, Dieffenbach, Aida K, Arndt, Volker, Park, Jong Y, Lin, Hui-Yi, Sellers, Thomas, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Batra, Jyotsna, Spurdle, Amanda, Clements, Judith A, Schleutker, Johanna, Nordestgaard, BØrge G, Wiklund, Fredrik, Travis, Ruth C, Haiman, Christopher A, Thibodeau, Stephen N, Maier, Christiane, Walther, Vogel, Blot, William J, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Pandha, Hardev, Teixeira, Manuel R, Cook, Margaret, Govindasami, Koveela, Guy, Michelle, Leongamornlert, Daniel, Sawyer, Emma J, Wilkinson, Rosemary, Morgan, Angela, Fisher, Cyril, Saunders, Edward J, Tymrakiewicz, Malgorzata, Livni, Naomi, Hazel, Steve, Dadaev, Tokhir, Cox, Angela, George, Anne, Lane, Athene, Marsden, Gemma, Davis, Michael, Brown, Paul, Pedersen, John, Hopper, John L, Karlsson, Ami, Cavalli-Bjoerkman, Carin, Adolfson, Jan, Johansson, Jan-Erik, Broms, Michael, Stattin, Paer, Kolb, Suzanne, Stegmaier, Christa, Zachariah, Babu, Park, Hyun, Haley, James, Pow-Sang, Julio, Rincon, Maria, Radlein, Selina, Vlahova, Aleksandrina, Mitkova, Atanaska, Kachakova, Darina, Popov, Elenko, Christova, Svetlana, Dikov, Tihomir, Eckert, Allison, Collins, Angus, Wood, Glenn, Malone, Greg, Alexander, Kimberly, Kerr, Kris, Kedda, Mary-Anne, Turner, Megan, Saunders, Pamela, Heathcote, Peter, Srinivasan, Srilakshmi, Omara, Tracy, Yeadon, Trina, Lose, Felicity, Easton, Douglas, Eeles, Rosalind A and Muir, Kenneth (2017) Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium British Journal of Cancer, 117 (5). pp. 734-743.

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Abstract

Background: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.

Methods: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.

Results: The results suggest that height is associated with high-grade prostate cancer risk. Men with height 4180cm are at a 22% increased risk as compared to men with height o173cm (OR 1.22, 95% CI 1.01–1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.

Conclusions: There was no evidence of gene-environment interaction between height and the selected candidate SNPs. Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Lophatananon, ArtitayaUNSPECIFIEDUNSPECIFIED
Stewart-Brown, SarahUNSPECIFIEDUNSPECIFIED
Kote-Jarai, ZsofiaUNSPECIFIEDUNSPECIFIED
Olama, Ali Amin AlUNSPECIFIEDUNSPECIFIED
Garcia, Sara BenllochUNSPECIFIEDUNSPECIFIED
Neal, David EUNSPECIFIEDUNSPECIFIED
Hamdy, Freddie CUNSPECIFIEDUNSPECIFIED
Donovan, Jenny LUNSPECIFIEDUNSPECIFIED
Giles, Graham GUNSPECIFIEDUNSPECIFIED
Fitzgerald, Liesel MUNSPECIFIEDUNSPECIFIED
Southey, Melissa CUNSPECIFIEDUNSPECIFIED
Pharoah, PaulUNSPECIFIEDUNSPECIFIED
Pashayan, NoraUNSPECIFIEDUNSPECIFIED
Gronberg, HenrikUNSPECIFIEDUNSPECIFIED
Wiklund, FredrikUNSPECIFIEDUNSPECIFIED
Aly, MarkusUNSPECIFIEDUNSPECIFIED
Stanford, Janet LUNSPECIFIEDUNSPECIFIED
Brenner, HermannUNSPECIFIEDUNSPECIFIED
Dieffenbach, Aida KUNSPECIFIEDUNSPECIFIED
Arndt, VolkerUNSPECIFIEDUNSPECIFIED
Park, Jong YUNSPECIFIEDUNSPECIFIED
Lin, Hui-YiUNSPECIFIEDUNSPECIFIED
Sellers, ThomasUNSPECIFIEDUNSPECIFIED
Slavov, ChavdarUNSPECIFIEDUNSPECIFIED
Kaneva, RadkaUNSPECIFIEDUNSPECIFIED
Mitev, VanioUNSPECIFIEDUNSPECIFIED
Batra, JyotsnaUNSPECIFIEDUNSPECIFIED
Spurdle, AmandaUNSPECIFIEDUNSPECIFIED
Clements, Judith AUNSPECIFIEDUNSPECIFIED
Schleutker, JohannaUNSPECIFIEDUNSPECIFIED
Nordestgaard, BØrge GUNSPECIFIEDUNSPECIFIED
Wiklund, FredrikUNSPECIFIEDUNSPECIFIED
Travis, Ruth CUNSPECIFIEDUNSPECIFIED
Haiman, Christopher AUNSPECIFIEDUNSPECIFIED
Thibodeau, Stephen NUNSPECIFIEDUNSPECIFIED
Maier, ChristianeUNSPECIFIEDUNSPECIFIED
Walther, VogelUNSPECIFIEDUNSPECIFIED
Blot, William JUNSPECIFIEDUNSPECIFIED
Kibel, Adam SUNSPECIFIEDUNSPECIFIED
Cybulski, CezaryUNSPECIFIEDUNSPECIFIED
Cannon-Albright, LisaUNSPECIFIEDUNSPECIFIED
Pandha, HardevH.Pandha@surrey.ac.ukUNSPECIFIED
Teixeira, Manuel RUNSPECIFIEDUNSPECIFIED
Cook, MargaretUNSPECIFIEDUNSPECIFIED
Govindasami, KoveelaUNSPECIFIEDUNSPECIFIED
Guy, MichelleUNSPECIFIEDUNSPECIFIED
Leongamornlert, DanielUNSPECIFIEDUNSPECIFIED
Sawyer, Emma JUNSPECIFIEDUNSPECIFIED
Wilkinson, RosemaryUNSPECIFIEDUNSPECIFIED
Morgan, AngelaUNSPECIFIEDUNSPECIFIED
Fisher, CyrilUNSPECIFIEDUNSPECIFIED
Saunders, Edward JUNSPECIFIEDUNSPECIFIED
Tymrakiewicz, MalgorzataUNSPECIFIEDUNSPECIFIED
Livni, NaomiUNSPECIFIEDUNSPECIFIED
Hazel, SteveUNSPECIFIEDUNSPECIFIED
Dadaev, TokhirUNSPECIFIEDUNSPECIFIED
Cox, AngelaUNSPECIFIEDUNSPECIFIED
George, AnneUNSPECIFIEDUNSPECIFIED
Lane, AtheneUNSPECIFIEDUNSPECIFIED
Marsden, GemmaUNSPECIFIEDUNSPECIFIED
Davis, MichaelUNSPECIFIEDUNSPECIFIED
Brown, PaulUNSPECIFIEDUNSPECIFIED
Pedersen, JohnUNSPECIFIEDUNSPECIFIED
Hopper, John LUNSPECIFIEDUNSPECIFIED
Karlsson, AmiUNSPECIFIEDUNSPECIFIED
Cavalli-Bjoerkman, CarinUNSPECIFIEDUNSPECIFIED
Adolfson, JanUNSPECIFIEDUNSPECIFIED
Johansson, Jan-ErikUNSPECIFIEDUNSPECIFIED
Broms, MichaelUNSPECIFIEDUNSPECIFIED
Stattin, PaerUNSPECIFIEDUNSPECIFIED
Kolb, SuzanneUNSPECIFIEDUNSPECIFIED
Stegmaier, ChristaUNSPECIFIEDUNSPECIFIED
Zachariah, BabuUNSPECIFIEDUNSPECIFIED
Park, HyunUNSPECIFIEDUNSPECIFIED
Haley, JamesUNSPECIFIEDUNSPECIFIED
Pow-Sang, JulioUNSPECIFIEDUNSPECIFIED
Rincon, MariaUNSPECIFIEDUNSPECIFIED
Radlein, SelinaUNSPECIFIEDUNSPECIFIED
Vlahova, AleksandrinaUNSPECIFIEDUNSPECIFIED
Mitkova, AtanaskaUNSPECIFIEDUNSPECIFIED
Kachakova, DarinaUNSPECIFIEDUNSPECIFIED
Popov, ElenkoUNSPECIFIEDUNSPECIFIED
Christova, SvetlanaUNSPECIFIEDUNSPECIFIED
Dikov, TihomirUNSPECIFIEDUNSPECIFIED
Eckert, AllisonUNSPECIFIEDUNSPECIFIED
Collins, AngusUNSPECIFIEDUNSPECIFIED
Wood, GlennUNSPECIFIEDUNSPECIFIED
Malone, GregUNSPECIFIEDUNSPECIFIED
Alexander, KimberlyUNSPECIFIEDUNSPECIFIED
Kerr, KrisUNSPECIFIEDUNSPECIFIED
Kedda, Mary-AnneUNSPECIFIEDUNSPECIFIED
Turner, MeganUNSPECIFIEDUNSPECIFIED
Saunders, PamelaUNSPECIFIEDUNSPECIFIED
Heathcote, PeterUNSPECIFIEDUNSPECIFIED
Srinivasan, SrilakshmiUNSPECIFIEDUNSPECIFIED
Omara, TracyUNSPECIFIEDUNSPECIFIED
Yeadon, TrinaUNSPECIFIEDUNSPECIFIED
Lose, FelicityUNSPECIFIEDUNSPECIFIED
Easton, DouglasUNSPECIFIEDUNSPECIFIED
Eeles, Rosalind AUNSPECIFIEDUNSPECIFIED
Muir, KennethUNSPECIFIEDUNSPECIFIED
Date : 1 August 2017
Identification Number : 10.1038/bjc.2017.231
Copyright Disclaimer : © The Author(s) named above, 2017. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords : Height; SNPs; Gene and environment interaction; Prostate cancer
Depositing User : Clive Harris
Date Deposited : 13 Sep 2017 11:39
Last Modified : 13 Sep 2017 11:39
URI: http://epubs.surrey.ac.uk/id/eprint/842264

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