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A single night light exposure acutely alters hormonal and metabolic responses in healthy participants

Albreiki, Mohammed S, Middleton, Benita and Hampton, Shelagh (2017) A single night light exposure acutely alters hormonal and metabolic responses in healthy participants Endocrine Connections, 6 (2). pp. 100-110.

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Abstract

Many animal studies have reported an association between melatonin suppression and the disturbance of metabolic responses; yet, few human studies have investigated bright light effects on metabolic and hormonal responses at night. This study investigated the impact of light on plasma hormones and metabolites prior to, and after, an evening meal in healthy participants. Seventeen healthy participants, 8 females (22.2 ± 2.59 years, mean ± s.d.) and 9 males (22.8 ± 3.5 years) were randomised to a two-way cross-over design protocol; dim light (DL) (<5 lux) and bright light (BL) (>500 lux) sessions, separated by at least seven days. Saliva and plasma samples were collected prior to and after a standard evening meal at specific intervals. Plasma non-esterified fatty acid (NEFA) levels were significantly higher pre-meal in DL compared to BL (P < 0.01). Plasma glucose and insulin levels were significantly greater post-meal in the BL compared to DL session (P = 0.02, P = 0.001), respectively. Salivary melatonin levels were significantly higher in the DL compared to those in BL session (P = 0.005). BL at night was associated with significant increases in plasma glucose and insulin suggestive of glucose intolerance and insulin insensitivity. Raised pre-prandial NEFA levels may be due to changes in insulin sensitivity or the presence of melatonin and/or light at night. Plasma triglyceride (TAG) levels were the same in both sessions. These results may explain some of the health issues reported in shift workers; however, further studies are needed to elucidate the cause of these metabolic changes.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Albreiki, Mohammed SUNSPECIFIEDUNSPECIFIED
Middleton, BenitaB.Middleton@surrey.ac.ukUNSPECIFIED
Hampton, ShelaghS.Hampton@surrey.ac.ukUNSPECIFIED
Date : 2017
Identification Number : 10.1530/EC-16-0097
Copyright Disclaimer : © 2017 The authors. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Uncontrolled Keywords : Metabolism; Melatonin; Light at night; Endogenous response
Depositing User : Clive Harris
Date Deposited : 08 Sep 2017 12:18
Last Modified : 31 Oct 2017 19:28
URI: http://epubs.surrey.ac.uk/id/eprint/842219

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