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m6A RNA methylation, a new hallmark in virus-host interactions

Brocard, Michele, Ruggieri, Alessia and Locker, Nicolas (2017) m6A RNA methylation, a new hallmark in virus-host interactions Journal of General Virology.

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Abstract

The role of m6A methylation of RNA has remained elusive for decades, however recent technological advances are now allowing the mapping of the m6A methylation landscape at nucleotide level. This has spurred an explosion in our understanding of the role played by RNA epigenetics in RNA biology. m6A modifications have been tied to almost every aspects of the mRNA life cycle and it is now clear that RNA virus genomes are subject to m6A methylation. These modifications play various roles in the viral replication cycle. This review will summarize recent breakthroughs concerning m6A RNA modification and their implications for cellular and viral RNAs.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Brocard, Michelem.brocard@surrey.ac.ukUNSPECIFIED
Ruggieri, AlessiaUNSPECIFIEDUNSPECIFIED
Locker, NicolasN.Locker@surrey.ac.ukUNSPECIFIED
Date : 2017
Copyright Disclaimer : © 2017 Microbiology Society
Uncontrolled Keywords : m6A methylation; Epitranscriptome; RNA; RNA virus
Depositing User : Clive Harris
Date Deposited : 31 Aug 2017 14:57
Last Modified : 31 Aug 2017 14:57
URI: http://epubs.surrey.ac.uk/id/eprint/842113

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